Photo of Qi (Tony) Zhou
Qi (Tony) Zhou
Associate Professor
University Faculty Scholar
Phone: 765-496-0707
Fax: 765-494-6545
E-mail: tonyzhou@purdue.edu
Specialization: pharmaceutical manufacturing of solid dosage forms, particle engineering, powder technology, surface characterization of pharmaceutical solids, inhalation formulation, pulmonary drug delivery system, dry powder inhaler
Education
2013-2015 NHMRC Early Career Fellow (=NIH K01), University of Sydney, Australia 2012-2013 Postdoctoral Research Fellow, University of Sydney, Australia 2011-2012 Postdoctoral Research Fellow, Monash University, Australia 2007-2011 PhD in Pharmacy, Monash University, Australia 2004-2008 MSc in Pharmacy, National University of Singapore, Singapore 1997-2001 BEng in Pharmaceutics, Shenyang Pharmaceutical University, China
Research

Dr. Zhou’s research focuses on: (1) particle engineering for innovative pharmaceutical manufacturing of solid dosage forms; (2) advanced characterization of pharmaceutical solids; (3) novel formulation design for pulmonary drug delivery systems.

Education

2013-2015 NHMRC Early Career Fellow (=NIH K01), University of Sydney, Australia
2012-2013 Postdoctoral Research Fellow, University of Sydney, Australia
2011-2012 Postdoctoral Research Fellow, Monash University, Australia
2007-2011 PhD in Pharmacy, Monash University, Australia
2004-2008 MSc in Pharmacy, National University of Singapore, Singapore
1997-2001 BEng in Pharmaceutics, Shenyang Pharmaceutical University, China

 

Research

Our research focuses on: (1) particle engineering for innovative pharmaceutical manufacturing of solid dosage forms; (2) advanced characterization of pharmaceutical solids; (3) novel formulation design for pulmonary drug delivery systems.

(1) Innovation is in great demand for pharmaceutical manufacturing aiming to improve the production efficiency of traditional small-molecule pharmaceutical products and to design suitable formulation for new biopharmaceutical entities. Our research is to apply novel particle engineering techniques such as spray drying and dry coating to design efficient manufacture process for solid dosage forms of both small- and large-molecule pharmaceuticals. 

(2) Characterization of solid surface properties is critical to ensure the manufacturability, stability and formulation performance of pharmaceutical solid dosage forms. Our research has developed an advanced surface characterization platform to achieve fundamental understanding in the impact of material surface properties on the formulation performance, including effect of surface composition on stability of amorphous solid dispersions and influence of surface properties on aerosol performance of dry powder inhalers.    

(3) Inhalation products become popular for treatment of pulmonary diseases because they can deliver the therapeutics directly to the site of diseases with potentially minimized systemic side effects and maximized treatment efficacy. Dr Zhou’s research is to design smart inhalation formulations for improved treatment of critical pulmonary diseases such as  lung infection.  

Lab Members
Maizbha Uddin Ahmed (Post-Doctoral Research Associate with Dr. Qi (Tony) Zhou)
Kinnari S. Arte (Graduate Student with Dr. Qi "Tony" Zhou)
Manlin Chen (Graduate Student)
Yijing Huang (Graduate Student with Dr. Qi (Tony) Zhou)
Vaibhav Pathak (Graduate Student with Dr. Qi (Tony) Zhou)
Chanakya D. Patil (Graduate Student with Dr. Qi "Tony" Zhou)
Shruti S. Sawant (Graduate Student with Dr. Qi)
Service and Engagement
, CPPR (Dane O. Kildsig) Center for Pharmaceutical Processing Research

2021-present   Scientific Advisor, Drug Delivery to Lungs Conference

2019                 Advisory Board, 3rd Annual Inhalation & Respiratory Drug Delivery Congress

2018                 Organizing Committee Co-Chair, 15th Garnet E. Peck Symposium

2014-2015        Executive Organizing Committee, Inhalation Asia 2015

2020-2023       Vice Chair, Inhalation and Nasal Community of American Associate of Pharmaceutical  Scientists (AAPS)

2022- present   Editorial Board Member, Journal of Pharmacy and Pharmacology

2021-present    Editorial Board Member, European Journal of Pharmaceutical Sciences

2021-present    Editorial Board Member, AAPS Open

2020-present    Editorial Board Member, International Journal of Pharmaceutics

2018-present    Editor, AAPS PharmSciTech

2018-present    Editorial Board Member, Pharmaceutical Research

2017-present    Editorial Advisory Board Member, Journal of Pharmaceutical Sciences

2017-present    Editorial Board Member, Current Pharmaceutical Design

2017-present    Editorial Board Member, Drug Development and Industrial Pharmacy

2022 Guest Editor, thematic issue of ‘Advances in pulmonary drug delivery systems and inhalation formulations’, Pharmaceutical Research.

2020 Guest Editor, thematic issue of “Advances in solid formulations of pharmaceutical biologics - formulation, manufacturing, characterization and stability”, Advanced Drug Delivery Reviews

2017 Guest Editor, thematic issue of ‘Formulation and Manufacturing of Solid Dosage Forms’, Pharmaceutical Research.

2015 Guest Editor, thematic issue of ‘Advances in powder engineering and technology for pharmaceutical solid dosage forms’, Current Pharmaceutical Design.

2014 Guest Editor, thematic issue of ‘Emerging formulation design and drug delivery systems for inhaled therapy’, Current Pharmaceutical Design.

Grant Reviewers: NIH, NSF, DoD etc. 

Honors and Credentials

2023        High Impact Paper Award, Acta Pharmaceutica Sinica B Journal.

2022        Young Investigator Award, Pharmaceutics Journal. 

2021        Emerging Leader Award, American Association of Pharmaceutical Scientists (AAPS)

2021        Award for Exceptional Teaching and Instructional Support during the COVID-19 Pandemic, Purdue University

2020        University Faculty Scholar Award, Purdue University

2020        Teaching & Learning Innovation Award, College of Pharmacy, Purdue University

2019        Emerging Scientist Award, The Aerosol Society

2019        Outstanding Reviewer Award, Journal of Pharmaceutical Sciences

2018        Rising Star Scholarship Award, National Institute for Pharmaceutical Technology & Education (NIPTE)

2018        Chaney Family Early Faculty Scholar Award, College of Pharmacy, Purdue University

2017        Showalter Trust Research Award, Ralph W. and Grace M. Showalter Research Trust

2017        New Investigator Award, International Society of Aerosols in Medicines (ISAM)

2016        Emerging Researcher Award, International Pharmaceutical Excipients Council of the Americas Foundation (IPEC)

2015        Postdoctoral Fellow Award, American Association of Pharmaceutical Scientists (AAPS)

2014        Australian Endeavor Fellowship, Australian Government

2013         Australian Biomedical Early Career Fellowship (equivalent to NIH K01), NHMRC

2012         Outstanding Graduate Student Research Award in Pharmaceutical Technologies, AAPS

2011        Postgraduate Publications Award, Monash University 

2010        Excipients Graduate Student Award, International Pharmaceutical Excipients Council of the Americas Foundation (IPEC)

2007-2011    International Postgraduate Research Scholarship, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University

2005-2007    University Research Scholarship, National University of Singapore

Grants

2023- 2024   Understanding the effect of excipients and interaction on physical stability of spray dried protein formulations. Merck Co. Role: Sole PI. $50,000.  

2023- 2024   Freeze-Thaw and Aseptic Drying Technology Roadmap for Pharma/Biotech Manufacturing. National Institute of Standards and Technology. Role: Co-I. Budget for Zhou $12,391. 

2022- 2023   Tunable RF/Microwave Drying of Biologics. National Institute for Innovation in Manufacturing Biopharmaceuticals Project fund. Role: Co-I. Budget for Zhou: $ 104,694.   

2022- 2023   Advanced Characterization and Manufacturing Methods for mRNA Vaccine Development. National Institute for Innovation in Manufacturing Biopharmaceuticals Project fund. Role: Co-I. Budget for Zhou: $68,396.   

2020-2021    Impact of excipients on spray dried proteins for inhalation products. NSF Center for Pharmaceutical Development project fund. Role: Sole PI. $50,000.

2020-2021    Effects of excipient on physical stability and aerosolization performance of spray dried proteins for dry powder inhaler formulations. Center for Pharmaceutical Processing Research Grant. Role: PI. $45,000.

2020-2021    Effect of Excipients on Stability of Spray Dried Protein Formulations. Merck Co. Role: Sole PI. $50,000.

2019-2024    Advancing innovative therapies against pandrug-resistant Gram-negative superbugs. NIH/NIAID 1R01AI146160. Role: PI. Total budget: $3,247,905.

2019-2020    Electrospray drying for protein formulations. Genentech. Role: PI. $50,000.

2019-2020    Understanding the effect of surface composition on stability of spray dried protein formulations. Center for Pharmaceutical Processing Research Grant. Role: PI. $45,000.  

2018-2019    An advanced surface characterization platform for fundamental understanding in aerosol performance of dry powder inhaler formulations. Center for Pharmaceutical Processing Research Grant partnered with AstraZeneca and Genentech. Role: Sole PI. $45,000.    

2017         Purdue College of Pharmacy Dean’s Summer Undergraduate Research Fellowship (Patricia Ahn). Role: Mentor. $5,000.

2017-2022    Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach. NIH/NIAID 1R01AI132681. Role: PI. Total funding: $2,403,074.

2017-2019   Novel inhalation therapies for treatment of fatal Gram-negative lung infections. Showalter Trust Research Award, Ralph W. and Grace M. Showalter Research Trust. Role: Sole PI. $75,000.

2017        Purdue College of Pharmacy Dean’s Summer Undergraduate Research Fellowship (Jiayang Huang). Role: Mentor. $5,000.

2017        On-line UPLC. Purdue University Core Facility Research Equipment Grant. PI Taylor LS. Role: Co-I.

2016-2021   Evaluate novel drug product manufacturing technologies. Bill & Melinda Gates Foundation Pilot Project. PI Taylor LS. Role: Co-I. Budget for Zhou: $200,000.  

2016       Purdue College of Pharmacy Dean’s Summer Undergraduate Research Fellowship (Kevin Bonar). Role: Mentor. $5,000.

2016        Advanced surface energy analyzer. Purdue University Major Scientific Equipment Grant. PI Pinal R. Role: Co-I.

2016        Developing powder aerosols of combinational antibiotics for combating life-threatening lung infections; Summer Faculty Grant, Purdue Research Foundation. Role: Sole PI. $10,000.   

2015-2017   Optimising inhaled polymyxins as a vital therapy for pulmonary infections: A novel biochemical, molecular imaging and systems pharmacology approach. NHMRC Project Grants (Australian equivalent of NIH R01) APP 1104581. PI Li J. Role: Co-I.

2014-2016   Novel inhalation formulation of colistin and combination therapy against Gram-negative 'superbugs'. NHMRC Project Grants (Australian equivalent of NIH R01) APP1065046. PI Chan H. Role: Co-I.

2013-2016   Inhaled antibiotic aerosols for respiratory infection treatment; Zhou Q; NHMRC Early Career Fellowships (Australian equivalent of NIH K01) APP1053528. Role: Sole PI.

Representative Publications

Full publication list: https://scholar.google.com/citations?user=KrwU6bQAAAAJ&hl=en

  1. Loo C, Lee W, Zhou QT*. 2023. Recent advances in inhaled nanoformulations of vaccines and therapeutics targeting respiratory viral infections. Pharmaceutical Research. 40:1015–1036.
  1. Mutukuri T, Ling J, Du Y, Su Y, Zhou QT*. Effect of Buffer Salts on Physical Stability of Lyophilized and Spray-Dried Protein Formulations Containing Bovine Serum Albumin and Trehalose. Pharmaceutical Research. Published: 28 June 2022.
  2. Mutukuri T, Darwish A, Strongrich AD, Peroulis D, Alexeenko A, Zhou QT*. Radio frequency - assisted ultrasonic spray freeze drying for pharmaceutical protein solids. Journal of Pharmaceutical Sciences. 112(1):40-50.
  3. Pathak V, Park H, Zemlyanov D, Bhujbal S, Ahmed M, Azad M, Li J, Zhou QT*. Improved aerosolization stability of inhalable tobramycin powder formulation by co-spray drying with colistin. Pharmaceutical Research. 39(11):2781-2799.
  4. Guan J, Yuan H, Yu S, Mao S, Zhou QT*. 2022. Spray Dried Inhalable Ivacaftor Co-Amorphous Microparticle Formulations with Leucine Achieved Enhanced In Vitro Dissolution and Superior Aerosol Performance. International Journal of Pharmaceutics. 622: 121859.
  5. Li M, Azad M, Ahmed M, Zhu Y, Song J, Zhou F, Chan H, Velkov T, Zhou QT, Li J. 2022. Polymyxin induces significant transcriptomic perturbations of cellular signalling networks in human lung epithelial cells. Antibiotics. 11(3):307.
  6. Bian X, Qu X, Zhang X, Nang S, Bergen P, Zhou QT, Chan H, Feng M, Li J. 2022. Pharmacokinetics and pharmacodynamics of peptide antibiotics. Advanced Drug Delivery Reviews. 183:114171.
  7. Kho Z, Azad M, Han M, Zhu, Y, Huang C, Schittenhelm R, Naderer T, Velkov T, Selkrig J, Zhou Q, Li J. 2022. Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages. PLOS Pathogens. 18(3):e1010308.
  8. Yu S, Pu X, Maizbha A, Yu H, Mutukuri T, Li J, Zhou QT* Spray-freeze-dried inhalable composite microparticles containing nanoparticles of combinational drugs for potential treatment of lung infections caused by Pseudomonas aeruginosa. International Journal of Pharmaceutics. 610:121160.
  9. Mutukuri, T., Maa, Y., Gikanga, B., Sakhnovksy, R., Zhou, Q.T.* Electrostatic Spray Drying for Monoclonal Antibody Formulation. International Journal of Pharmaceutics. 607:120942.
  10. Bhujbal, S., Su, Y., Pathak V., Zemlyanov, D., Cavallaro, A., Munson, E., Taylor, L., Zhou, Q.T.* 2021 Effect of storage humidity on physical stability of spray dried amorphous solid dispersions: two fluid nozzle vs. three fluid nozzle. 13:7, 1074.
  11. Ahmed, M., Azad, M., Li, M., Creek, D., Han, M., Zhou, F., Chan, H., Zhou, Q., Velkov, T., and Li, J. 2021. Polymyxins induced metabolic perturbations in human lung epithelial cells. Antimicrobial Agents and Chemotherapy. 65:9, e00835-21.
  12. Chen, Y., Ling, J., Li, M., Su, Y., Arte, K., Mutukuri, T., Taylor, L., Munson, E., Topp, E., Zhou, Q.T.* Understanding the Impact of Protein Excipient Interactions on Physical Stability of Spray-Dried Protein Solids. Molecular Pharmaceutics. 18:7, 2657–2668.
  13. Bhujbal, S., Mitra, B., Jain, U., Gong, Y., Agrawal, A., Karki, S., Taylor, L., Kumar, S.,* Zhou, Q. T.* Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies. Acta Pharmaceutica Sinica B. 11:8, 2505-2536.   
  1. Wickremasinghe, H., Yu, H., Azad, M., Zhao, J., Bergen, P., Velkov, T., Zhou, Q.T., Zhu, Y., Li, J. 2021. Clinically relevant concentrations of polymyxin B and meropenem synergistically kill multidrug-resistant Pseudomonas aeruginosa and minimise biofilm formation. 10:4, 405.
  2. Almangour, T.A., Garcia, E., Zhou, Q., Forrest, A., Kaye, K., Li, J., Velkov, Y., Rao, G. 2021. Polymyxins for the treatment of lower respiratory tract infections: lessons learned from the integration of clinical pharmacokinetic studies and clinical outcomes. International Journal of Antimicrobial Agents. 57:6, 106328.
  3. Yuan, H., Yu, S., Chai, G., Liu, J., Zhou, Q.T.* A LC-MS/MS method for simultaneous analysis of the cystic fibrosis therapeutic drugs colistin, ivacaftor and ciprofloxacin. Journal of Pharmaceutical Analysis. 11:6, 732-738.
  4. Chen, Y., Mutukuri, T.T., Wilson, N.E., Zhou, Q.T.* Pharmaceutical protein solids: drying technology, solid-state characterization and stability. Advanced Drug Delivery Reviews.172: 211-233.
  5. Azad, M.A.K., Zhang, S., Li, J., Kim, Y., Yu, H., Fulcher, A.J., Howard, D., de Jonge, M., James, S., Roberts, K., Velkov, T., Fu, J., Zhou, Q.T.,* Li, J. 2021. Synchrotron-based X-ray fluorescence microscopy reveals accumulation of polymyxins in single human alveolar epithelial cells. Antimicrobial Agents and Chemotherapy. 65(5):e02314-20.
  6. Zhao, J., Han, M., Zhu, Y., Lin, Y., Wang, Y., Lu, J., Hu, Y., Zhou, Q. T., Velkov, V., Li, J. 2021. Comparative metabolomics reveals key pathways associated with the synergistic activity of polymyxin B and rifampicin combination against multidrug-resistant Acinetobacter baumannii. Biochemical Pharmacology. 184: 114400.
  7. Chen, J., Maizbha, A., Zhu, C., Yu, S., Pan., W., Velkov, T., Li, J., Zhou, Q.T.* In vitro evaluation of drug delivery behavior for inhalable amorphous nanoparticle formulations in a human lung epithelial cell model. International Journal of Pharmaceutics. 596: 120211.
  8. Mutukuri, T., Wilson, N., Taylor, L., Topp, E., Zhou, Q.T.* Effects of Drying Method and Excipient on the Structure and Physical Stability of Protein Solids: Freeze Drying vs. Spray Freeze Drying. International Journal of Pharmaceutics. 594: 120169.
  9. Nang, S., Azad, M.A.K., Velkov, T., Zhou, Q.T.,* Li, J.* 2021. Rescuing the last-line polymyxins: Achievements and challenges. Pharmacological Reviews. 73:2, 679-728.
  10. Bhujbal, S., Pathak., V., Zemlyanov, D.Y., Taylor, L.S. Zhou, Q.T.* Physical stability and dissolution of lumefantrine amorphous solid dispersions produced by spray anti-solvent precipitation. Journal of Pharmaceutical Sciences. 110:6, 2423-2431.
  11. Lin, Y., Aye, S.M., Rao, G., Zhou, Q.T., Chan, H.K., Li, J. 2020. Treatment of Infections Caused by Gram-negative Pathogens: Current Status on the PK/PD of Parenteral and Inhaled Polymyxins in Patients. International Journal of Antimicrobial Agents. 56:6, 106199.
  12. Shetty, N., Zhang, Y., Park, H., Zemlyanov, D.Y., Shah, D., He, A., Ahn, P., Mutukuri, T., Chan, H., Zhou, Q.* Surface composition and aerosolization stability of an inhalable combinational powder formulation spray dried using a three-fluid nozzle. Pharmaceutical Research. 37: 219. #
  13. Hussein, M., Hu, X., Paulin, O.K.A., Crawford, S., Zhou, Q.T., Baker, M., Schneider-Futschik, E., Zhu, Y., Li, J., Velkov, T. 2020. Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens. Computational and Structural Biotechnology Journal. 18, 2247-2258. #
  14. Trasi, N., Bhujbal, S., Zemlyanov, D.Y., Zhou, Q., Taylor, L.S. 2020. Physical stability and release properties of lumefantrine amorphous solid dispersion granules prepared by a simple solvent evaporation approach. International Journal of Pharmaceutics:X. 2: 100052. #
  15. Zhu, C., Chen, J., Yu, S., Que, C., Taylor, L., Tan, W., Wu, C., Zhou, Q.* Inhalable nano-composite microparticles with enhanced dissolution and superior aerosol performance. Molecular Pharmaceutics. 17:9, 3270–3280. #
  16. Park, H., Nie, H., Dhiman, A., Tomar, V., Zhou, Q.* Understanding dynamics of polymorphic conversion during tableting process using an in situ mechanical Raman spectroscopy. Molecular Pharmaceutics. 17: 8, 3043–3052. #
  17. Chai, G., Hassan, A., Meng, T., Lou, L., Ma, J., Simmers, R., Zhou, L., Rubin, B., Zhou, Q.T., Longest, W., Hindle, M., Xu Q. 2020. Dry powder aerosol containing muco-inert particles for excipient enhanced growth pulmonary drug delivery. Nanomedicine: Nanotechnology, Biology, and Medicine. 29, 102262. #
  18. Fathalla, A., Chow, S., Naderer, T., Zhou, Q., Velkov, T., Azad, M., Li. J. 2020. Polymyxin-induced cell death of human macrophage-like THP-1 and neutrophil-like HL-60 cells associated with the activation of apoptotic pathways. Antimicrobial Agents and Chemotherapy. 64(9):e00013-20. #
  19. Yu, S., Yuan, H., Chai, G., Peng, K., Zou, P., Li, X., Li, J., Zhou, F., Chan, H., Zhou, Q.T.* 2020. Optimization of inhalable liposomal powder formulations and evaluation of their in vitro drug delivery behavior in Calu-3 human lung epithelial cells. International Journal of Pharmaceutics. 586:119570. #
  20. Hussein, M., Schneider-Futschik, E, Paulin, O., Allobawi, R., Crawford, S., Zhou, Q.T., Hanif, A., Baker, M., Zhu, Y., Li, J., Velkov, T. 2020. Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline. ACS Infectious Diseases. 6, 6, 1436–1450. #
  21. Hussein, M., Han, M., Zhu, Y., Zhou, Q., Lin, Y., Hancock, R., Hoyer, D., Creek, D., Li, J., Velkov, T. Metabolomics study of the synergistic killing of polymyxin B in combination with amikacin against polymyxin-susceptible and resistant Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 20;64(1). pii: e01587-19. #
  22. Lu, P., Xing, Y., Peng, H., Liu, Z.,* Zhou, Q.T.,* Xue, Z., Ma, Z., Kebebe, D., Zhang, B., Liu, H. 2020. Physicochemical and pharmacokinetic evaluation of spray-dried co-formulation of Salvia miltiorrhiza polyphenolic acid and L-leucine with improved bioavailability. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 33, 2. #
  23. Shetty, N., Cipolla, D., Park, H., Zhou, Q.T.* Physical Stability of Dry Powder Inhaler Formulations. Expert Opinion on Drug Delivery. 17:1, 77-96. #
  24. Yu, S., Wang, S., Lin, Y., Zou, P., Chai, G., Lin, Y., Velkov, T. Li, J., Zhou, Q.T.* Inhalable Liposomal Powder formulations for Co-delivery of Synergistic Ciprofloxacin and Colistin against Multi-drug Resistant Gram-negative Lung Infections. International Journal of Pharmaceutics. 575:15, 118915. #
  25. Wilson, N., Mutukuri, T., Zemlyanov D., Taylor, L., Topp, E.,* Zhou, Q.T.* Surface Composition and Formulation Heterogeneity of Protein Solids Produced by Spray Drying. Pharmaceutical Research. 37:1, 14. #
  26. Trasi, N., Bhujbal, S., Zhou, Q.T., Taylor, L.S. 2019. Amorphous Solid Dispersion Formation via Solvent Granulation - A Case Study with Ritonavir and Lopinavir. International Journal of Pharmaceutics:X. 1: 100035. #
  27. Lin, Y., Han, M., Zhao, J., Zhu, Y., Rao, G., Forrest, A., Song, J., Kaye, K., Hertzong, P., Purcell, A., Creek, D., Zhou, Q.T., Velkov, T., Li, J. 2019. Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-resistant Pseudomonas aeruginosa. Frontiers in Pharmacology. 10:1146. #
  28. Chai, G., Park, H., Yu, S., Zhou, F., Li, J., Xu, Q., Zhou, Q.T. * Evaluation of Co-delivery of Colistin and Ciprofloxacin in Liposomes Using an In Vitro Human Lung Epithelial Cell Model. 2019. International Journal of Pharmaceutics. 569, 118616. #
  29. Mangal, S., Park, H., Nour, R., Shetty, N., Cavallaro, A., Zemlyanov, Thalberg, K., Puri, V., Nicholas, M., Narang, A., Zhou, Q.T.* Correlations between surface composition and aerosolization of jet-milled dry powder inhaler formulations with pharmaceutical lubricants. International Journal of Pharmaceutics. 567, 118470. #
  30. Wilson, N., Topp, E., Zhou, Q.T.* Effects of Drying Method and Excipient on Structure and Stability of Protein Solids Using Solid-State Hydrogen/Deuterium Exchange Mass Spectrometry (ssHDX-MS). International Journal of Pharmaceutics. 567, 118470. #
  31. Ling, J., Mangal, S., Wang, S., Cavallaro, A., Zhou, Q.T.* Simultaneous particle size reduction and homogeneous mixing to produce combinational powder formulations for inhalation by the single-step co-jet-milling. Journal of Pharmaceutical Sciences. 108 (9), 3146-3151. #
  32. Lu, P., Xing, Y., Xue, Z., Ma, Z., Zhang, B., Peng, H., Zhou, Q., Liu, H., Liu, Z., Li, J. Pharmacokinetics of Salvianolic acid B, Rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution. 2019. Biomedical Chromatography. 33(8), e4561. #
  33. Mangal, S., Huang, J., Shetty, N., Park, H., Lin, Y., Yu, Y., Zemlyanov, D., Velkov, T., Li, J., Zhou, Q.T.* Effects of antibiotic component on in-vitro bacterial killing, physico-chemical properties, aerosolization and dissolution of a ternary-combinational inhalation powder formulation of antibiotics for pan-drug resistant Gram-negative lung infections. International Journal of Pharmaceutics. 561, 102-113. #
  34. Lin, Y., Rahim, N., Zhao, J., Han, M., Yu, H., Wickremasinghe, H., Chen K., Wang, J., Paterson, D., Zhu, Y., Rao, G., Zhou, Q.T., Forrest, A., Velkov, T., Li, J. Novel Polymyxin Combination with Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-producing MDR Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. 63 (4), e02176-18. #
  35. Zhou, Q.T.,* Li, T. Formulation and Manufacturing of Solid Dosage Forms. 2019. Pharmaceutical Research. 36 (1), 16. (Editorial) #
  36. Mangal, S., Xu., R., Park, H., Zemlyanov, D., Shetty, N., Lin, Y., Morton, D., Chan, H.K., Li, J., Zhou, Q.T.* Understanding the impacts of surface compositions on the in-vitro dissolution and aerosolization of co-spray-dried composite powder formulations for inhalation. Pharmaceutical Research. 36 (1), 6. #
  37. Hussein, M., Han, M., Zhu, Y., Schneider-Futschik, E.K., Hu, X., Zhou, Q.T., Lin, Y., Anderson, D., Creek, D.J., Hoyer, D., Li, J., Velkov, T. 2018. Mechanistic insights into synergistic bactericidal effect of a polymyxin B combination with tamoxifen against cystic fibrosis MDR Pseudomonas aeruginosa. Computational and Structural Biotechnology Journal. 16, 587-599. #
  38. Huang, Z., Lin, L., Goverin, C., Liu, H., Wang, L., Zhou, Q.T., Lu, M., Wu, C. 2018. Dry powder inhaler formulations of poorly water-soluble itraconazole: A balance between in-vitro dissolution and in-vivo distribution is necessary. International Journal of Pharmaceutics. 551(1-2), 103-110. #
  39. Ahmed, M. U. Velkov, T., Zhou, Q., Fulcher, A., Callaghan, J., Zhou, F., Chan, H., Azad, M., Li, J. 2018. Intracellular localisation of polymyxins in human alveolar epithelial cells. Journal of Antimicrobial Chemotherapy. 74 (1), 48-57. #
  40. Jasim, R., Han, M., Zhu, Y., Hu, X., Hussein, M., Lin, Y., Zhou, Q. T., Dong, C., Li, J., Velkov, T. 2018. Lipidomic analysis of the outer membrane vesicles from paired polymyxin-susceptible and -resistant Klebsiella pneumoniae clinical isolates. International Journal of Molecular Sciences. 19(8), E2356. #
  41. Wang, S., Yu, S., Lin, Y., Zou, P., Chai, G., Yu, H.H., Wickremasinghe, H., Shetty, N., Ling, J., Li, J., Zhou, Q.T.* Co-delivery of ciprofloxacin and colistin in liposomal formulations with enhanced in vitro antimicrobial activities against multidrug resistant Pseudomonas aeruginosa. Pharmaceutical Research. 35(187), 1-13. #
  42. Shetty, N., Ahn, P., Park, H., Bhujbal, S., Zemlyanov D., Cavallaro, A., Mangal, S., Li, J., Zhou, Q.T.* Improved physical stability and aerosolization of inhalable amorphous ciprofloxacin powder formulations by incorporating synergistic colistin. Molecular Pharmaceutics. 15 (9), 4004–4020. #
  43. Mangal, S., Park, H., Zeng, L., Yu, Y., Lin, Y., Velkov, T., Deman, J., Zemlyanov, D., Li, J., Zhou, Q.T.* Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation. International Journal of Pharmaceutics. 548(1), 443-453. #
  44. Bhujbal, S., Zemlyanov, D., Cavallaro, A., Mangal, S., Taylor, L., Zhou, Q. T.* 2018. Qualitative and quantitative characterization of composition heterogeneity on the surface of spray dried amorphous solid dispersion particles by an advanced surface analysis platform with high surface-sensitivity and superior spatial resolution. Molecular Pharmaceutics. 15(5), 2045-2053. #
  45. Shetty, N., Park, H., Zemlyanov D., Mangal, S., Bhujbal, S., Zhou, Q.T.* Influence of excipients on physical and aerosolization stability of spray dried high-dose powder formulations for inhalation. International Journal of Pharmaceutics. 554(1), 222-234. #
  46. Lin, Y., Chen K., Wang, J., Velkov, T., Zhou, Q.T., Li, J. 2018. A proof-of-concept study of the efficacy of systemically administered polymyxins in mouse burn wound infection caused by multidrug-resistant Gram-negative pathogens. Antimicrobial Agents and Chemotherapy. 62(5), e02527-17. #
  47. Lu, X., Chan, T., Zhu, L., Bao, X., Velkov, T., Zhou, Q. T., Li, J., Chan, H., Zhou, F. 2018. The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models. European Journal of Pharmaceutical Sciences. 115, 132-143. #
  48. Mangal, S., Nie, H., Xu, R., Guo, R., Cavallaro, A., Zemlyanov, D., Zhou, Q.T.* Physico-chemical Properties, Aerosolization and Dissolution of Co-spray Dried Azithromycin Particles with L-Leucine for Inhalation. Pharmaceutical Research. 35 (2), 28. #
  49. Lin, Y., Zhou, Q.T., Han M., Chen K., Onufrak, N.J., Wang, J., Howden, B., Turnidge J., Forrest, A., Chan, H., Li, J. 2018. Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy. 62 (2), e01790-17. #
  50. Moussa, E.M., Wilson, N., Zhou, Q.T., Singh, S.K., Nema, S., Topp, E.M. 2018. Effects of the drying process on an IgG1 monoclonal antibody using solid-state hydrogen deuterium exchange with mass spectrometric analysis (ssHDX-MS). Pharmaceutical research, 35(1), 12. #
  51. Shetty, N., Zeng, L., Mangal, S., Nie, H., Rowles, M.R., Guo, R., Han, Y., Park, J., Zhou, Q.T.* 2018. Effects of Moisture-induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations. Pharmaceutical Research. 35 (1), 7. #
  52. Lin, Y., Zhou, Q.T., Han M., Onufrak, N.J., Chen K., Wang, J., Forrest, A., Chan, H., Li, J. 2018. Mechanism-based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy. 62 (3), e01965-17. #
  53. Lin, Y., Zhou, Q.T., Hu, Y., Onufrak, N.J., Sun, S., Wang, J., Forrest, A., Chan, H., Li, J. Pulmonary Pharmacokinetics of Colistin Following Administration of Dry Powder Aerosols in Rats. Antimicrobial Agents and Chemotherapy. 61 (11), e00973-17. #
  54. Li, L., Leung, S.S.Y., Gengenbach, T., Yu, J., Gao, G.F., Tang, P., Zhou, Q.T., Chan, H.K. 2017, Investigation of L-leucine in reducing the moisture-induced deterioration of spray-dried salbutamol sulfate power for inhalation. International Journal of Pharmaceutics, 530(1-2), 30-39. #

 

  1. Lin, Y., Zhou, Q.T., Onufrak, N.J., Wirth, V., Chen, K., Forrest, A., Wang, J., Chan, H., Li, J. 2017, Aerosolized Polymyxin B for Treatment of Respiratory Tract Infections: Determination of Pharmacokinetic/Pharmacodynamic Indices for Aerosolized Polymyxin B against Pseudomonas aeruginosa in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy, 61(8), e00211-17. #
  2. Wei G., Mangal, S., Denman J., Gengenbach, T., Bonar, K.L., Khan, R. I., Qu, L., Li, T., Zhou, Q.T. * 2017, Effects of coating materials and processing conditions on flow enhancement of cohesive acetaminophen powders by high-shear processing with pharmaceutical lubricants. Journal of Pharmaceutical Sciences, 106(10) 3022-3032. #
  3. Ahmed, M., Velkov, T., Lin, Y., Yun, B., Nowell, C., Zhou, F., Zhou, Q., Chan, H., Azad, M., Li, J. 2017, Potential toxicity of polymyxins in human lung epithelial cells. Antimicrobial Agents and Chemotherapy, 61(6), e02690-16. #
  4. Nie, H., Byrn, S., Zhou, Q.T.* Stability of pharmaceutical salts in solid oral dosage forms. 2017, Drug Development and Industrial Pharmacy, 43(8), 1215-1228. # (Top ten most downloaded paper in 2017)
  5. Mangal, S., Gao, W., Li, T., Zhou, Q.T.* Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers: challenges and opportunities. 2017, Acta Pharmacologica Sinica, 38, 782-797. #
  6. Lin, Y, Zhou, Q.T.*, Cheah, S., Zhao, J., Chen, K., Wang, J., Chan, H.*, Li, J. Pharmacokinetics/Pharmacodynamics of Pulmonary Delivery of Colistin against Pseudomonas aeruginosa in a Mouse Lung Infection Model. 2017, Antimicrobial Agents and Chemotherapy, 61(3), e02025-16. #
  7. Qu, L., Stewart, P.J., Hapgood, K., Satu Lakio, Morton, D.A.V.*, Zhou, Q.T.* Single-step co-processing of cohesive powder via mechanical dry coating for direct tablet compression. 2017, Journal of Pharmaceutical Sciences, 106(1), 159–167. #
  8. Zhou, Q.T., Loh, Z.H., Yu, J.Q., Sun, S., Gengenbach, T., Denman, J., Li, J., Chan, H.K. How much surface coating of hydrophobic azithromycin is sufficient to prevent moisture-induced decrease in aerosolisation of hygroscopic colistin powder? 2016, AAPS Journal, 18(5), 1213-1224. #
  9. Schneider, E., Azad, M., Han, M., Zhou, Q., Wang, J., Huang, J., Cooper, M., Doi, Y., Baker, M., Bergen, P., Muller, M., Li, J., Velkov, T. An ‘unlikely’ pair: The antimicrobial synergy of polymyxin B in combination with the cystic fibrosis trans-membrane conductance regulator drugs KALYDECO and ORKAMBI. 2016, ACS Infectious Diseases, 2(7), 478-488. #
  10. Leung, C.M.S., Tong, Z., Zhou, Q.T., Chan, J.G.Y., Tang, P., Sun, S., Yang, R., Chan, H.K. Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-based DPI Formulations. Part 1: Grid Structure. 2016, AAPS Journal, 18(5), 1159-1167. #
  11. Qu, L., Morton, D.A.V., Zhou, Q.T.*, Particle Engineering by Practical and Scalable Intensive Mechanical Dry Coating Processes to Develop Highly-Efficient Dry Powder Inhaler Formulations. 2016, Inhalation, 10(3), 17-22. #
  12. Jong, T., Li, J., Morton, D.A.V.,* Zhou, Q.T.,* Larson, I.* Investigation of the changes in aerosolization behavior between the jet-milled and spray-dried colistin powders through surface energy characterization. 2016, Journal of Pharmaceutical Sciences, 105(3), 1156–1163. #
  13. Wang, W. , Zhou, Q.T., Sun S., Denman J., Gengenbach, T., Barraud, N., Rice, S.A., Li, J., Yang, M., Chan, H.K. Effects of surface composition on the aerosolisation and dissolution of inhaled antibiotic combination powders consisting of colistin and rifampicin. 2016, AAPS Journal, 18(2) 372-384 ( co-first authors). #
  14. Jin, L., Zhou, Q.T., Chan, H.K., Larson, I., Pennington, W.M., Boyd, J.B., Norton, S.R., Nicolazzo, A.J. Pulmonary delivery of the Kv1.3-blocking peptide HsTX1[R14A] for the treatment of autoimmune diseases, 2016, Journal of Pharmaceutical Sciences, 105(2), 650–656. (Virtual Issue – Most Original and Most Significant Scientific Findings) #
  15. Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, H., Li, J., Zhou, F. Human Oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins, 2016, Journal of Antimicrobial Chemotherapy. 71 (2), 403-412. #
  16. Zhou, Q.T., Chan, H.K. Emerging formulation design and drug delivery systems for inhaled therapy. 2015. Current Pharmaceutical Design, 21 (40), pp. 5749-5750. (Editorial) #
  17. Zhou, Q.T., Morton, D.A.V. Advances in particle engineering and powder technology for pharmaceutical solid dosage forms. 2015. Current Pharmaceutical Design, 21 (27), pp. 3852. (Editorial) #
  18. Qu, L., Morton, D.A.V.*, Zhou, Q.T.* Particle engineering via mechanical dry coating in the design of pharmaceutical solid dosage forms, 2015, Current Pharmaceutical Design. 21 (40), 5802-5814. #
  19. Lin, Y., Wong, J., Chan, H. K.*, Zhou, Q. T.* Powder production and particle engineering for dry powder inhaler formulations, 2015, Current Pharmaceutical Design. 21(27), pp. 3902-3916. #
  20. Leung, S.S.Y., Tang, P., Zhou, Q.T., Tong, Z., Leung, C., Decharaksa, J., Yang, R., Chan, H.K. De-agglomeration effect of the United States Pharmacopeia and Alberta throats on carrier-based powders in commercial inhalation products, 2015, AAPS Journal. 17 (6), pp. 1407-1416.
  21. Qu, L., Zhou, Q.T., Denman, J., Stewart, P.J., Hapgood, K., Morton, D.A.V. Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders, 2015, European Journal of Pharmaceutical Sciences.78, pp. 264–272.
  22. Zhou, Q. T., Sun, S.; Chan, J., Wang, P., Barraud, N., Rice, S., Wang, J., Li, J., Chan, H. K. Novel inhaled combination powder containing amorphous colistin and crystalline rifapentine with enhanced antimicrobial activities against planktonic cells and biofilm of Pseudomonas aeruginosa for respiratory infection. 2015. Molecular Pharmaceutics. 12 (8), pp. 2594–2603.
  23. Velkov, T., Abdulrahim, N., Zhou, Q.T., Chan, H.K., Li, J., Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead. 2015. Advanced Drug Delivery Reviews 85, pp. 65-82. (Top 1% highly cited paper in Pharmacology & Toxicology by Web of Science as of March/April 2016)
  24. Zhou, Q.T., Leung, S.S.Y., Tang, P., Thaigarajan, P., Loh Z.H., Chan, H.K., Inhalation formulation and drug delivery systems for respiratory infections. 2015. Advanced Drug Delivery Reviews 85, pp. 83-99. (Top 1% highly cited paper in Pharmacology & Toxicology by Web of Science as of March/April 2016)
  25. Qu, L., Zhou, Q.T., Gengenbach, T., Denman, J., Hapgood, K., Gamlen, M., Stewart, P.J., Morton, D.A.V., Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. 2015. Drug Development and Industrial Pharmacy 41 (5), pp. 825-837.
  26. Liang, W., Lau, P.N.N., Zhou, Q.T., Chow, M.Y.T., Kwok, P.C.L., Leung, G.P.H., Mason, A.J., Chan, H.K., Poon, L.L.M., Lam, J.K.W., Inhalable dry powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza. 2015. Molecular Pharmaceutics 12 (3), pp. 910 -921.
  27. Rajkhowa, R., Abdullah, K., Zhou Q.T., Kondor A., Morton D.A.V., Wang X. Relationship between processing, surface energy and bulk properties of ultrafine silk particles. 2015. Powder Technology 270, pp. 112-120.
  28. Zhou, Q.T., Tang, P., Leung, S.S.Y., Chan, J.G.Y., Chan, H.K., Emerging inhalation aerosol devices and strategies: where are we headed? Advanced Drug Delivery Reviews, 75, pp. 3-17.
  29. Chan, J.G.Y., Wong, J., Zhou, Q.T., Leung, S.S.Y., Chan, H.K., Advances in device and formulation technologies for pulmonary drug delivery. AAPS PharmSciTech, 15(4), pp. 882-897.
  30. Zhou, Q.T., Gengenbach, T., Denman, J. A., Yu, H. H., Li, J., Chan, H.K. Synergistic antibiotic combination powders of colistin and rifampicin provide high aerosolization efficiency and moisture protection. 2014. AAPS Journal, 16(1), pp. 38-47.
  31. Zhou, Q.T., Morton, D. A.V., Yu, H. H., Jacob, J., Wang, J., Li, J., Chan, H.K. Colistin Powders with High Aerosolisation Efficiency for Respiratory Infection: Preparation and In Vitro 2013. Journal of Pharmaceutical Sciences, 102 (10), pp. 3736-3747.
  32. Zhou, Q.T., Tong, Z., Tang, P., Yang, R., Chan, H.K. Effect of device design on the aerosolization of a carrier-based dry powder inhaler- A case study on Aerolizer Foradile. 2013. AAPS Journal, 15 (2), pp. 511-522.
  33. Zhou, Q.T.*, Li, Qu, Gengenbach, T., Larson, I., Stewart, P.J., Morton, D.A.V.* Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. 2013. AAPS PharmSciTech, 14, pp. 38-44.
  34. Zhou, Q.T., Morton, D.A.V. Drug-Lactose Binding Aspects in Adhesive Mixtures: Controlling performance in Dry Powder Inhaler Formulations by Altering Lactose Carrier Surfaces. 2012. Advanced Drug Delivery Reviews, 64 (3), pp. 275-284. (Cover page)
  35. Rajkhowa, R., Zhou, Q., Tsuzuki, T., Morton D.A.V., Wang, X., Ultrafine wool powders and their bulk properties. 2012. Powder Technology, 224 (3), pp. 183-188.
  36. Zhou, Q.T., Gengenbach, T., Denman, J., Das, S., Li, Qu, Zhang H.L., Larson, I., Stewart, P.J., Morton, D.A.V. Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach, 2011. Journal of Pharmaceutical Sciences, 100 (8), pp. 3421-3430.
  37. Zhou, Q.T., Li, Qu, Larson, I., Stewart, P.J., Morton, D.A.V. Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: a model cohesive pharmaceutical powder. 2011. Powder Technology, 207 (1-3), pp. 414-427.
  38. Zhou, Q.T., Li, Qu, Gengenbach, T., Denman, J., Larson, I., Stewart, P.J., Morton, D.A.V. Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties. 2011. International Journal of Pharmaceutics, 413 (1-2), pp. 36-43.
  39. Das, S.C., Zhou, Q., Morton, D.A.V., Larson, I., Stewart, P.J. Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. 2011. European Journal of Pharmaceutical Sciences, 43 (4), pp. 325-333.
  40. Zhou, Q., Armstrong, B., Larson, I., Stewart, PJ., Morton D.A.V., Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating. 2010. Journal of Pharmaceutical Sciences, 99 (2), pp. 969-981.
  41. Zhou, Q.T., Armstrong, B., Larson, I., Stewart, P.J., Morton, D.A.V., Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders. 2010. European Journal of Pharmaceutical Sciences, 40 (5), pp. 412-421.
  42. Zhou, Q.T., Li, Qu, Larson, I., Stewart, P.J., Morton, D.A.V. Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach. 2010. International Journal of Pharmaceutics, 394 (1-2), pp. 50-59.
  43. Zhou, Q., Armstrong, B., Larson, I., Stewart, PJ., Morton D.A.V., Effect of host particle size on the modification of powder flow behaviours of lactose monohydrate following dry coating. 2010. Dairy Science and Technology, 90 (2-3), pp. 237-251.
  44. Zhu, K., Tan, R.B.H., Kiong Ng, W., Shen, S., Zhou, Q., Heng, P.W.S. Analysis of the influence of relative humidity on the moisture sorption of particles and the aerosolization process in a dry powder inhaler. 2008. Journal of Aerosol Science, 39 (6), pp. 510-524.
  45. Chan, L.W., Zhou, Q., Heng, P.W.S. Comparison of surface roughness parameters obtained by scanning probe microscopy for carrier particles of dry powder inhalers. 2007. Journal of Drug Delivery Science and Technology, 17 (3), pp. 217-222.
  46. Karande, A. D., Zhou, Q., Chan, L. W., Heng, P. W. S. and Liew, C. V. Scanning Probe Microscopy for Surface Roughness Characterization of Lactose Carriers Used in Dry Powder Inhalation Therapy. 2007. Journal of Scanning Probe Microscopy, 2, pp. 5-9.