Photo of Eric J. Munson
Eric J. Munson
Dane O. Kildsig Chair in Industrial and Physical Pharmacy, Department Head
Phone: 765-494-1450
Fax: 765-494-6545
E-mail: munsone@purdue.edu
Specialization: Solid state formulation, Formulation design, Protein design, stability and formulation, Pharmaceutical solids, Phase transformations, Physical and chemical stability, Water-solid interactions, and Amorphous systems & solid dispersions
Education
1988-93 Ph.D. Chemistry Dissertation Title - In Situ Solid-State Nuclear Magnetic Resonance Studies of Reactions in Zeolite Catalysts Doctoral Advisor - Professor James F. Haw Texas A&M University, College Station, Texas 1987-88 Fulbright Fellow Technical University of Munich, Munich, West Germany 1983-87 B.A., Summa Cum Laude Augustana College, Sioux Falls, South Dakota Major: Chemistry, Physics / Minor: Mathematics
Research

Dr. Munson is a world expert in the characterization of pharmaceutical solids using a variety of analytical techniques, with an emphasis on solid-state spectroscopy.  His group focuses on several areas of research that encompass small and large molecule formulations and drug delivery.  Interests include the characterization of amorphous solid dispersions, including investigating drug-polymer interactions and homogeneity, and how this impacts functional properties such as crystallization; biological systems, including proteins and mRNA LNPs, for predicting stability in lyophilized matrices; and excipients, such as magnesium stearate, and how crystalline form impacts functional properties.

Lab Members
Daniel F. DeNeve (Graduate Student with Dr. Eric Munson)
Nicholas J. (Nick) Huls (Post-Doctoral Research Associate with Dr. Eric Munson)
Rachana Sapkota (Graduate Student with Dr. Eric Munson)
Md Abdullah Shamim (Graduate Student with Dr. Eric Munson)
Cole Tower (Graduate Student with Dr. Eric Munson)
Ziqian Wei (Graduate Student with Dr. Eric Munson)
Jianchao Xu (Graduate Student with Dr. Eric Munson)
Tianyun (Ophelia) Zhang (Graduate Student w Dr. Eric Munson)
Interests

- Pharmaceutical solids

- Solid-state NMR spectroscopy

- Characterization

- Amorphous solid dispersions

- Lyophilized formulations

- 3D printing

- Complex formulations, including PLGA and complex matrices

 

Service and Engagement

- US Pharmacopeia - Chair of Simple Excipients Committee

 

Administration and Committee Work

Department Head - Industrial and Physical Pharmacy

Representative Publications

Jarrells, TW: Munson, EJ: “Comparison of Differential Scanning Calorimetry, Powder X-ray Diffraction, and Solid-state Nuclear Magnetic Resonance Spectroscopy for Measuring Crystallinity in Amorphous Solid Dispersions-Application to Drug-in-Polymer SolubilityJournal of Pharmaceutical Sciences, 2022, 35421430

Chen, Y.; Moseson, D.; Richard, C.; Swinney, M.; Horava, S.; Oucherif, K.; Cox, A.; Hawkins, E.; Li, Y.; DeNeve, D.; Munson, E.; et al. “Development of Hot-Melt Extruded Drug/Polymer Matrices for Sustained Delivery of MeloxicamJournal of Controlled Release, 2022, 342, 189-200.

Lu, X.; Li, M.; Arce, F.; Ling, J.; Setiawan, N.; Wang, Y.; Shi, X.; Campbell, H.; Nethercott, M.; Xu, W.; Munson, E.; Marsac, P.; Su, Y.; “Mechanistic Investigation of Drug Supersaturation in the Presence of Polysorbates as Solubilizing Additives by Solution Nuclear Magnetic Resonance Spectroscopy”  Molecular Pharmaceutics, 2021, 18, 12, 4310-4321.

Bhujbal, S.; Su, Y.; Pathak, V.; Zemlyanov, D.; Cavallaro, A.; Munson, E.; Taylor, L.; Zhou, Q.; “Effect of Storage Humidity on Physical Stability of Spray-Dried Naproxen Amorphous Solid Dispersions with Polyvinylpyrrolidone: Two Fluid Nozzle vs. Three Fluid Nozzle”  Pharmaceutics, 2021, 13, 7, 1074.

Zhou, Q.; Munson, E.; “Advances in Solid Formulation of Pharmaceutical Biologics” Advanced Drug Delivery Reviews, 2021, 175, 113827.

Chen, Y.; Ling, J.; Li, MY; Su, YC; Arte, KS; Mutukuri, TT; Taylor, LS; Munson, EJ; Topp, EM; Zhou, QT “Understanding the Impact of Protein-Excipient Interactions on Physical Stability of Spray-Dried Protein Solids”, Mol. Pharm., 2021, 18, 2657-68.

Sarpal, K.; Munson, EJ;  “Amorphous Solid Dispersions of Felodipine and Nifedipine with Soluplus (R): Drug-Polymer Miscibility and Intermolecular InteractionsJ. Pharm. Sci., 2021, 110, 4, 1457-1469.

Li, M.; Koranne, S.; Fang, R.; Lu, XY.; Williams, D. M.; Munson, EJ.; Bhambhani, A.;Su, YC. “Probing Microenvironmental Acidity in Lyophilized Protein and Vaccine Formulations Using Solid-state NMR SpectroscopyJ. Pharm. Sci., 2021, 110, 3, 1292-1301.

Hancock, M. L.; Yokel, R. A.; Beck, M. J.; Calahan, J. L.; Jarrells, T. W.; Munson, E. J.; Olaniyan, G. A.; Grulke, E. A. “The characterization of purified citrate-coated cerium oxide nanoparticles prepared via hydrothermal synthesisApp. Surf. Sci., 2021, 535, Article Number: 147681.

Calahan, J. L.; Paul, S.; Yanez, E. G.; DeNeve, D.; Sun, C. Q. C.; Munson, E. J. “The impact of solid-state form, water content, and surface area of magnesium stearate on lubrication efficiency, tabletability, and dissolutionPharm. Dev. Tech., 2021, 26, 150-156.

Jarrells, T. W.; Zhang, D.; Li, S.; Munson, E. J. “Quantification of Monomer Units in Insoluble Polymeric Active Pharmaceutical Ingredients Using Solid-State NMR Spectroscopy I: PatiromerAAPS PharmSciTech, 2020, 21, Article Number: 116.

Sarpal, K.; Tower, C; Munson, E. J. “Investigation into Intermolecular Interactions and Phase Behavior of Binary and Ternary Amorphous Solid Dispersions of KetoconazoleMol. Pharm. 2020, 17, 787-801.

Dachavaram, S. S.; Moore, J. P.; Bommagani,S.; Penthala, N. R.; Calahan, J. L.; Delaney, S. P.; Munson, E. J. Batta-Mpouma, J.; Kim, J. W.; Hestekin, J. A.; Crooks, P. A.; “A Facile Microwave Assisted TEMPO/NaOCl/Oxone (KHSO5) Mediated Micron Cellulose Oxidation Procedure: Preparation of two Nano TEMPO-Cellulose Forms” Starch. 202072, Article Number: 1900213.

Sarpal, K.; Delaney, S.; Zhang, G. G. Z.; Munson, E. J. “Phase Behavior of Amorphous Solid Dispersions of Felodipine: Homogeneity and Drug-Polymer InteractionsMol. Pharm. 2019, 16, 4836-4851.

Honick, M.; Sarpal, K.; Alayoubi, A.; Zidan, A.; Hoag, S. W.; Hollenbeck, R. G.; Munson, E. J.; Polli, J. E. “Utility of Films to Anticipate Effect of Drug Load and Polymer on Dissolution Performance from Tablets of Amorphous Itraconazole Spray-Dried DispersionsAAPS PharmSciTech, 2019, 20 (331), 1-13.

Dachavaram, S. S.; Penthala, N. R.; Calahan, J. L.; Munson, E. J.; Crooks, P. A. “Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers”, Organic and Biomolecular Chemistry, 2018, 16, 6057-6062.

Kalra, A., Lubach, J. W.; Munson, E. J.; Li, T. “Exploring Molecular Speciation and Crystallization Mechanism of Amorphous 2-Phenylamino Nicotinic AcidPharmaceuticaal Research, 2018, 35, 51.

Hanrahan, M., Venkatesh, A., Carnahan, J., Lunach, J. Munson, E.j.; & Rossini, A. "Enhancing the resolution of 1H and 13C solid-state NMR spectra by reduction of anisotropic bulk magnetic susceptibility broadening." Physical Chemistry Chemical Physics; PCCP, 2017, 19(41), 28153-28162

Kalra, A., Tishmack, P., Lubach, J., Munson, E., Taylor, L., Byrn, S., & Li, T. "Impact of Supramolecular Aggregation on the Crystallization Kinetics of Organic Compounds from the Supercooled Liquid State"Molecular Pharmaceutics, 2017, 14, 2126-2137.

Dempah, K.E.; Lubach, J.W.; Munson, E'J' "Characterization of the Particle Size and Polydispersity of Dicumarol Using Solid-State NMR Spectroscopy" Molecular Pharm., 2017, 14, 856-865. (Correction for lead author, 2017, 14, 1319-1319).

Delaney, S.P.; Nethercott, M.J.; Mays, C.J.; Winquist, N.T.; Arthur, D.; Calahan, J.L.; Sethi, M.; Pardue, D.S.; Kim, J.; Amidon, G.; Munson, E.J. "Characterization of Synthesized and Commercial Forms of Magnesium Stearate Using Differential Scanning Calorimetry, Thermogravimetric Analysis, Powder X-Ray Diffraction, and Solid-State NMR Spectroscopy", J. Pharm. Sci, 2017, 106, 338-347.

Tang, S.; Bhandari, R.; Delaney, S.P.; Munson, E.J.; Dziubla, T.D.; Hilt, J.Z. "Synthesis and characterization of thermally responsive N-isopropylacrylamide hydrogels copolymerized with novel hydrophobic polyphenolic crosslinkers" Materials Today Comm., 2017, 10, 46-53.

Jennings, J.A.; Parkin, S.; Munson, E.; Delaney, S.P.; Calahan, J.L.; Isaacs, M.; Hong, K.; Crocker, M. "Regioselective Baeyer-Villiger oxidation of lignin model compounds with tin beta zeolite catalyst and hydrogen peroxide" RSC Advances, 2017, 7, 25987-25997.

Mensink, M.A.; Nethercott, M.; Hinriches, W.L.; van der Voort Maarschalk, K.; Friklink, H.W.; Munson, E.J.; Pikal, M.J. "Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability" AAPS J, 2016.

Haware, R.V.; Dave, V.S.; Kakarala, B.; Delaney, S.; Staton, S.; Munson, E.; Gupta, M.R.; Stagner, W.C.; "Vegetable-derived magnesium stearate functionality evaluation by DM(3) approach" Eur J Pharm Sci., 2016, 89, 115-124.