Photo of Lynne S. Taylor
Lynne S. Taylor
Retter Distinguished Professor of Pharmacy
Phone: 765-496-6614
Fax: 765-494-6545
E-mail: lstaylor@purdue.edu
Specialization: Solubility Enhancement, Amorphous Formulations, Delivery of bRO5 Molecules, Phase Behavior, Crystallization, Salts, Water-Solid Interactions, Spray Drying, Hot Melt Extrusion, Bioavailability
Education
Bachelor of Pharmacy with Honors, University of Bath, UK, 1990 PhD, Pharmaceutical Technology, University of Bradford, UK, 1996 Post-doctoral Research Associate, University of Wisconsin-Madison 1996-1998 Associate Principal Scientist, AstraZeneca R&D, Mölndal, Sweden, 1998-2003
Research

Emerging drug candidates are increasing in complexity, making them very hard to deliver due to their sub-optimal physicochemical properties. Typically, new drugs either have low solubility or low permeability, or in the worse case scenario, low solubility and low permeability. This is especially true for many new types of therapeutics which have high molecular weights (beyond rule of 5 compounds) such as PROTACs and peptides, making their oral delivery very challenging. Fortunately, for many of these molecules, oral absorption can be potentially improved through carefully engineering formulations to improve solubility and/or permeability. Solubility enhancement can often be achieved, for example, with amorphous formulations. By mixing with a suitable polymer, improved dissolution rates, solution concentrations and enhanced absorption can often be achieved. However, these advantages come at a cost, including higher risk due to crystallization, larger dosage forms sizes, and more complex manufacturing processes. Poorly permeable molecules such as peptides also require excipients to promote oral absorption, and this is an exciting emerging area within our group. Another area of interest is improving the delivery of poorly water soluble drugs important for global health. This includes research with drugs important for TB and malaria treatment. Thus, we seek to understand  problematic drugs and their formulations at a fundamental level to maximize oral delivery through smart formulation design. We collaborate broadly with many other scientists to help us in this pursuit and use a variety of analytical approaches to characterize these complex systems.    

 

Lab Members
Pradnya P. Bapat (Graduate Student)
Emily G. Benson (Graduate Student)
Amanpreet Kaur Chahal (Post-Doctoral Research Associate)
Michelle Lauren Cousineau (Graduate Student)
Benedito Roberto De Alvarenga Jr. (Post-Doctoral Research Associate)
Van Tu Duong (Post-Doctoral Research Associate)
Sheena Lee Nuera Luy (Graduate Student)
Mennatallah A. Mohamed (Graduate Student)
Simisola Temidayo Oloye (Graduate Student)
Neha S. Panchabhai (Graduate Student)
Stella P. Petrova (Post-Doctoral Research Associate with Dr. Taylor)
Dishan D. Shah (Graduate Student)
Taiga Uekusa (Post-Doctoral Research Associate)
Interests

We are very interested in phase transitions and their impact on drug release. Recently, we have pioneered the use of confocal fluorescence microscopy to study phase behavior at the interface between an amorphous solid dispersion and the aqueous solution, linking visual observations to release performance.  

We also focus heavily on drug-excipient interactions, and how these impact drug release and absorption. In particular, we have targeted drug-polymer and drug-surfactant interactions, and drug and excipient distribution in phase separated systems. A variety of spectroscopic techniques have been key for understanding these topics.

Surface properties and engineering are also crucial to optimize formulations. The surface is the first site of engagement of a particle with other formulation components as well as aqueous media. We have studied the influence of surface composition on performance, as well as surface engineering via nanocoating.  

Teaching

IPPH 580

Honors and Credentials
Representative Publications

All publications

Hiew, T. N. and Taylor, L. S. (2022). Combining drug salt formation with amorphous solid dispersions – a double edged sword. Journal of Controlled Release. 353:47-60.

Moseson, D.E., Benson, E.G., Nguyen, H.T., Wang, F., Wang, M., Zheng, K., Narwankar, P.K. and Taylor, L.S. (2022). Atomic Layer Coating to Inhibit Surface Crystallization of Amorphous Pharmaceutical Powders. ACS Applied Materials & Interfaces, 14(36):40698-40710.

Correa Soto, C.E., Gao, Y., Indulkar, A.S., Zhang, G.G. and Taylor, L.S. (2022). Role of Surfactants in Improving Release from Higher Drug Loading Amorphous Solid Dispersions. International Journal of Pharmaceutics. 625:122120.

Sabra, R., Narula, A., Taylor, L.S. and Li, N. (2022). Comparisons of in Vitro Models to Evaluate the Membrane Permeability of Amorphous Drug Nanoparticles. Molecular Pharmaceutics. 19(9):3412-3428.

Qi, Q. and Taylor, L.S. (2022). Improved Dissolution of an Enteric Polymer and its Amorphous Solid Dispersions by Polymer Salt Formation. International Journal of Pharmaceutics. 622:121886.

Novo, D.C., Gao, C., Qi, Q., Mosquera-Giraldo, L.I., Spiering, G.A., Moore, R.B., Taylor, L.S. and Edgar, K.J. (2022). Designing synergistic crystallization inhibitors: Bile salt derivatives of cellulose with enhanced hydrophilicity. Carbohydrate Polymers, 292:119680.

Razumtcev, A., Li, M., Rong, J., Teng, C.C., Pfluegl, C., Taylor, L.S. and Simpson, G.J., 2022. Label-Free Autofluorescence-Detected Mid-Infrared Photothermal Microscopy of Pharmaceutical Materials. Analytical Chemistry, 94(17):6512-6520.

Hate, S.S., Mosquera-Giraldo, L.I. and Taylor, L.S. (2022). A Mechanistic Study of Drug Mass Transport from Supersaturated Solutions Across PAMPA Membranes. Journal of Pharmaceutical Sciences, 111(1):102-115.

Chen, Y.C., Moseson, D.E., Richard, C.A., Swinney, M.R., Horava, S.D., Oucherif, K.A., Cox, A.L., Hawkins, E.D., Li, Y., DeNeve, D.F. and Lomeo, J., Zhou, A., Lyle, T. L., Munson, E. J., Taylor, L.S., Park, K. and Yeo, Y. (2022). Development of hot-melt extruded drug/polymer matrices for sustained delivery of meloxicam. Journal of Controlled Release. 342:189-200.

Indulkar, A.S., Lou, X., Zhang, G.G. and Taylor, L.S. (2022). Role of Surfactants on Release Performance of Amorphous Solid Dispersions of Ritonavir and Copovidone. Pharmaceutical Research, 39(2):381-397.

Van Duong, T., Ni, Z. and Taylor, L.S., (2022). Phase Behavior and Crystallization Kinetics of a Poorly Water-Soluble Weakly Basic Drug as a Function of Supersaturation and Media Composition. Molecular Pharmaceutics.19(4):1146-1159.

Yang, R., Zhang, G.G., Kjoller, K., Dillion, E., Purohit, H.S. and Taylor, L.S., (2022). Phase separation in surfactant-containing amorphous solid dispersions: orthogonal analytical methods to probe the effects of surfactants on morphology and phase composition. International Journal of Pharmaceutics. 619:121708.

Van Duong, T., Nguyen, H.T. and Taylor, L.S., (2022). Combining enabling formulation strategies to generate supersaturated solutions of delamanid: in situ salt formation during amorphous solid dispersion fabrication for more robust release profiles. European Journal of Pharmaceutics and Biopharmaceutics. 174:131-143.

Hiew, T.N., Zemlyanov, D.Y. and Taylor, L.S., (2022). Balancing solid-state stability and dissolution performance of lumefantrine amorphous solid dispersions: the role of polymer choice and drug–polymer interactions. Molecular Pharmaceutics. 19(2):392-413.

Van Duong, T., Nguyen, H.T., Wang, F., Wang, M., Narwankar, P.K. and Taylor, L.S., (2022). Surface nanocoating of high drug-loading spray-dried amorphous solid dispersions by atomic layer coating: Excellent physical stability under accelerated storage conditions for two years. International Journal of Pharmaceutics. 620:121747.

Moseson, D.E., Eren, A., Altman, K.J., Corum, I.D., Li, M., Su, Y., Nagy, Z.K. and Taylor, L.S., (2022) Optimization of Amorphization Kinetics during Hot Melt Extrusion by Particle Engineering: An Experimental and Computational Study. Crystal Growth & Design. 22(1):821-841.

Alvarenga Jr, B.R.D., Moseson, D.E., Carneiro, R.L. and Taylor, L.S., (2022). Impact of Polymer Type on Thermal Degradation of Amorphous Solid Dispersions Containing Ritonavir. Molecular Pharmaceutics. 19(1):332-344.

Correa Soto, C., Gao, Y., Indulkar, A. S., Ueda, K., Zhang, G. G. Z., and Taylor, L. S. (2022). Impact of Surfactants on the Performance of Clopidogrel-Copovidone Amorphous Solid Dispersions: Increased Drug Loading and Stabilization of Nanodroplets. Pharmaceutical Research. 39:167-188.

Ueda, K., Higashi, K., Moribe, K. and Taylor, L.S., (2022). Variable-Temperature NMR Analysis of the Thermodynamics of Polymer Partitioning between Aqueous and Drug-Rich Phases and Its Significance for Amorphous Formulations. Molecular Pharmaceutics. 19(1):100–114.

Li, M., Razumtcev, A., Yang, R., Liu, Y., Rong, J., Geiger, A. C., Blanchard, R., Pfluegl, C., Taylor, L. S., Simpson, G. J. (2021).  Fluorescence-Detected Mid-Infrared Photothermal Microscopy. Journal of the American Chemical Society. 143(29): 10809-10815.

Que, C., Deac, A., Zemlyanov, D.Y., Qi, Q., Indulkar, A.S., Gao, Y., Zhang, G.G. and Taylor, L.S. (2021). Impact of Drug–Polymer Intermolecular Interactions on Dissolution Performance of Copovidone-Based Amorphous Solid Dispersions. Molecular Pharmaceutics, 18(9):3496-3508.

Abouselo, A., Rance, G.A., Tres, F., Taylor, L.S., Kwokal, A., Renou, L., Scurr, D.J., Burley, J.C. and Aylott, J.W. (2021). Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging. Molecular Pharmaceutics, 18(9):3247-3259.

Yang, R., Mann, A.K., Van Duong, T., Ormes, J.D., Okoh, G.A., Hermans, A. and Taylor, L.S. (2021). Drug Release and Nanodroplet Formation from Amorphous Solid Dispersions: Insight into the Roles of Drug Physicochemical Properties and Polymer Selection. Molecular Pharmaceutics. 18(5):2066-2081.

Elkhabaz, A., Moseson, D.E., Sarkar, S., Brouwers, J., Simpson, G.J., Augustijns, P. and Taylor, L.S. (2021). Crystallization Kinetics in Fasted-State Simulated and Aspirated Human Intestinal Fluids. Crystal Growth & Design. 21(5):2807-2820.

Saboo, S., Bapat, P., Moseson, D. E., Kestur, U. S., Taylor, L. S. (2021). Exploring the Role of Surfactants in Enhancing Drug Release from Amorphous Solid Dispersions at Higher Drug Loadings. Pharmaceutics. 13(5): 735.

Bhujbal, S. V., Pathak, V., Zemlyanov, D. Y., Taylor, L. S., Zhou, Q. (2021)  Physical Stability and Dissolution of Lumefantrine Amorphous Solid Dispersions Produced by Spray Anti-Solvent Precipitation. Journal of Pharmaceutical Sciences. 110(6):2423-2431.

Chen, Y., Ling, J., Li, M., Su, Y., Arte, K. S., Mutukuri, T. T., Taylor, L. S., Munson, E. J., Topp, E. M., Zhou, Q. T. (2021). Understanding the Impact of Protein–Excipient Interactions on Physical Stability of Spray-Dried Protein Solids. Molecular Pharmaceutics 18(7):2657-2668.

Moseson, D. E., Corum, I. D., Lust, A., Altman, K. J., Hiew, T. N., Eren, A., Nagy, Z. K., and Taylor. L. S. (2021) Amorphous Solid Dispersions Containing Residual Crystallinity: Competition Between Dissolution and Matrix Crystallization. The AAPS Journal 23(4):1-18

Bhujbal, S. V, Su, Y., Pathak, V., Zemlyanov, D. Y. Cavallaro, A. A., Munson, E. J., Taylor, L. S., and Zhou, Q. T. (2021) Effect of Storage Humidity on Physical Stability of Spray-Dried Naproxen Amorphous Solid Dispersions with Polyvinylpyrrolidone: Two Fluid Nozzle vs. Three Fluid Nozzle. Pharmaceutics 13(7):1074.

Voelker, A.L., Taylor, L. S. and Mauer, L. J. (2021). Effect of pH and concentration on the chemical stability and reaction kinetics of thiamine mononitrate and thiamine chloride hydrochloride in solution. BMC chemistry 15(1): 1-14

Parker, A. P., Taylor, L.S., and Beaudoin, S. P. (2021) Polymer effects on crystallization at the amorphous atazanavir-water interface. Journal of Crystal Growth 571:126254

Pepin, X. J. H., Dressman, J.,  Parrott, N.,  Delvadia, P.,  Mitra, A., Zhang, X.,  Babiskin, A.,  Kolhatkar, V.,  Seo, P.,  Taylor, L. S.,  Sjogren, E.,  Butler, J. M.,  Kostewicz, E.,  Tannergren, C.,  Koziolek, M.,  Kesisoglou, F.,  Dallmann, A.,  Zhao, Y., Suarez-Sharp, S. (2021). In Vitro Biopredictive Methods: A Workshop Summary Report. Journal of Pharmaceutical Sciences. 110(2):567-583.

Voelker, A.L., Taylor, L. S. and Mauer, L. J. (2021). Chemical stability and reaction kinetics of thiamine mononitrate in the aqueous phase of bread dough. Food Research International. 140: 110084.

Wilson, V.R., Mugheirbi, N.A., Mosquera-Giraldo, L.I., Deac, A., Moseson, D.E., Smith, D.T., Novo, D.C., Borca, C.H., Slipchenko, L.V., Edgar, K.J. and Taylor, L.S. (2021). Interaction of Polymers with Enzalutamide Nanodroplets—Impact on Droplet Properties and Induction Times. Molecular Pharmaceutics. 18(3): 836–849.

Ueda, K., and Taylor, L. S. (2021). Partitioning of surfactant into drug-rich nanodroplets and its impact on drug thermodynamic activity and droplet size. Journal of Controlled Release. 330: 229-243.

Voelker, A.L., Felton. C., Taylor, L. S. and Mauer, L. J. (2021). Effects of polyphenols on crystallization of amorphous sucrose lyophiles. Food Chemistry. 338: 128061.

Ueda, K., Moseson, D. E., Pathak, V., and Taylor, L. S. (2021). Effect of Polymer Species on Maximum Aqueous Phase Supersaturation Revealed by Quantitative Nuclear Magnetic Resonance Spectroscopy. Molecular Pharmaceutics. 18(3):1344–1355.

Mutukuri, T. T.,  Wilson, N. E.,  Taylor, L. S.,  Topp, E. M.,  Zhou, Q. T. (2021). Effects of drying method and excipient on the structure and physical stability of protein solids: Freeze drying vs. spray freeze drying. International Journal of Pharmaceutics. 594:20169.

Moseson, D. E.;  Jordan, M. A.;  Shah, D. D.;  Corum, I. D.;  Alvarenga, B. R., Jr.; Taylor, L. S. (2020). Application and limitations of thermogravimetric analysis to delineate the hot melt extrusion chemical stability processing window. International Journal of Pharmaceutics. 590:119916.

Li, N.,  Cape, J. L.,  Mankani, B. R.,  Zemlyanov, D. Y.,  Shepard, K. B.,  Morgen, M. M., Taylor, L. S. (2020) Water-Induced Phase Separation of Spray-Dried Amorphous Solid Dispersions. Molecular Pharmaceutics. 17(10):4004-4017.

Arioglu-Tuncil, S.,  Voelker, A. L., Taylor, L. S.,  Mauer, L. J., (2020). Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions. International Journal of Molecular Science. 21(24):9370.

Arioglu-Tuncil, S., Voelker, A. L., Taylor, L. S.,  Mauer, L. J. (2020). Amorphization of Thiamine Chloride Hydrochloride: Effects of Physical State and Polymer Type on the Chemical Stability of Thiamine in Solid Dispersions. International Journal of Molecular Science. 21(16):5935.

Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2020). Influence of Drug-Silica Electrostatic Interactions on Drug Release from Mesoporous Silica-Based Oral Delivery Systems. Molecular Pharmaceutics. 17(9):3435-3446.

Zhu, C., Chen, J., Yu, S., Que, C., Taylor, L. S., Tan, W., Wu, C, Zhou, Q. R. (2020). Inhalable nano-composite microparticles with enhanced dissolution and superior aerosol performance. Molecular Pharmaceutics. 17(9):3270-3280.

Saboo, S., Moseson, D. E., Kestur, U. S., Taylor, L. S.  (2020). Patterns of drug release as a function of drug loading from amorphous solid dispersions: A comparison of five different polymers. European Journal of Pharmaceutical Sciences. 155:105514

Wilson, V., Lou, X., Osterling, D. J., Stolarik, D. F., Jenkins, G. J., Nichols, B., Dong, Y., Edgar, K. J., Zhang, G. G. Z., and Taylor, L. S. (2020) Amorphous Solid Dispersions of Enzalutamide and Novel Polysaccharide Derivatives: Investigation of Relationships between Polymer Structure and Performance. Scientific Reports. 10(1): 1-12.

Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2020). Interplay of Adsorption, Supersaturation and the Presence of an Absorptive Sink on Drug Release from Mesoporous Silica-Based Formulations. Pharmaceutical Research. 37(8):1-18.

McCarthy, C. A., Zemlyanov, D., Crean, A. M., Taylor, L. S. (2020). Comparison of Drug Release and Adsorption Under Supersaturating Conditions for Ordered Mesoporous Silica with Indomethacin or Indomethacin Methyl Ester. Molecular Pharmaceutics. 17(8): 3062–3074.

Enright, E. F., Joyce, S. A., Gahan, C. G. M., Taylor, L. S. (2020) Impact of phospholipid digests and bile acid pool variations on the crystallization of atazanavir from supersaturated solutions. European Journal of Pharmaceutics and Biopharmaceutics. 153: 68-83.

Ueda, K., and Taylor, L. S. (2020). Impact of hypromellose acetate succinate grade on drug amorphous solubility and in vitro membrane transport. Journal of Pharmaceutical Sciences. 109(8): 2464-2473.

Trasi, N. S., Bhujbal, S.V., Zhou, Q. T., and Taylor, L. S. (2020). Physical Stability and Release Properties of Lumefantrine Amorphous Solid Dispersion Granules Prepared by a Simple Solvent Evaporation Approach. International Journal of Pharmaceutics: X. 2:100052.

Ueda, K., and Taylor, L. S. (2020). Polymer type impacts amorphous solubility and drug-rich phase colloidal stability: A mechanistic study using nuclear magnetic resonance spectroscopy. Molecular Pharmaceutics. 17(4):1352-1362.

Saboo, S. S., Kestur, U. S., Flaherty, D. P., Taylor, L. S. (2020) Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of drug-polymer hydrogen bonding, surface crystallization and glass transitionMolecular Pharmaceutics. 17(4): 1261–1275.

Que, C., Qi, Q., Zemlyanov, D. Y., Mo, H., Deac, A., Zeller, M., Indulkar, A. S., Gao, Y., Zhang, G. G. Z., and Taylor, L. S. (2020). Evidence for Halogen Bonding in Amorphous Solid Dispersions. Crystal Growth and Design. 20 (5): 3224–3235.

Parker, A. S., Taylor, L. S., and Beaudoin, S. P. (2020). The Role of Surface Energy Heterogeneity on Crystal Morphology during Solid-State Crystallization at the Amorphous Atazanavir-Water Interface. CrysEngComm. 22, 3179-3187.

Moseson, D.E., Parker, A.S., Beaudoin, S.P., and Taylor, L.S., (2020) Amorphous Solid Dispersions Containing Residual Crystallinity: Influence of Seed Properties and Polymer Adsorption on Dissolution Performance. European Journal of Pharmaceutical Sciences. 146: 105276.

Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2020). Absorptive dissolution testing: An improved approach to study the impact of residual crystallinity on the performance of amorphous formulations. Journal of Pharmaceutical Sciences. 109(3): 1312-1323.

Wilson, N.E., Mutukuri, T.T., Zemlyanov, D.Y., Taylor, L. S., Topp, E.M., Zhou, Q. T. (2020). Surface Composition and Formulation Heterogeneity of Protein Solids Produced by Spray Drying. Pharmaceutical Research. 37(1):14.

Sherman, A. M., Geiger, A. C., Smith, C., Taylor, L. S. Hinds, J., Stroud, P., Simpson, G. J. (2020). Stochastic Differential Scanning Calorimetry by Nonlinear Optical Microscopy. Analytical Chemistry. 92(1): 1171-1178.

Indulkar, A. S., Raina, S. A., Gao, Y., Zhang, G. G. Z., and Taylor, L. S. (2020). Impact of monomeric vs. micellar surfactant and surfactant-polymer interactions on nucleation-induction times of atazanavir from supersaturated solutions. Crystal Growth and Design. 20(1):62-72.

Dening, T. J.; Zemlyanov, D.; Taylor, L. S.  Application of an adsorption isotherm to explain incomplete drug release from ordered mesoporous silica materials under supersaturating conditions. Journal of Controlled Release 2019, 307, 186-199.

Dong, Y.; Novo, D. C.; Mosquera-Giraldo, L. I.; Taylor, L. S.; Edgar, K. J.  Conjugation of bile esters to cellulose by olefin cross-metathesis: A strategy for accessing complex polysaccharide structures. Carbohydrate Polymers 2019, 221, 37-47.

Elkhabaz, A.; Sarkar, S.; Simpson, G. J.; Taylor, L. S.  Characterization of Phase Transformations for Amorphous Solid Dispersions of a Weakly Basic Drug upon Dissolution in Biorelevant Media. Pharmaceutical Research 2019, 36, (12), 174.

Indulkar, A. S.; Gao, Y.; Raina, S. A.; Zhang, G. G. Z.; Taylor, L. S.  Impact of Monomeric versus Micellar Surfactant and Surfactant–Polymer Interactions on Nucleation–Induction Times of Atazanavir from Supersaturated Solutions. Crystal Growth & Design 2019, 20, (1), 62-72.

Indulkar, A. S.; Lou, X.; Zhang, G. G. Z.; Taylor, L. S.  Insights into the Dissolution Mechanism of Ritonavir–Copovidone Amorphous Solid Dispersions: Importance of Congruent Release for Enhanced Performance. Molecular Pharmaceutics 2019, 16, (3), 1327-1339.

Li, N.; Taylor, L. S.  Microstructure formation for improved dissolution performance of lopinavir amorphous solid dispersions. Molecular Pharmaceutics 2019, 16, (4), 1751-1765.

Mauer, L. J.; Forny, L.; Meunier, V. D. M.; Taylor, L. S.  Optimizing the Quality of Food Powder Products: The Challenges of Moisture-Mediated Phase Transformations. Annual Review of Food Science and Technology 2019, 10, 457-478.

Moseson, D. E.; Parker, A. S.; Gilpin, C. J.; Stewart, A. A.; Beaudoin, S. P.; Taylor, L. S.  Dissolution of indomethacin crystals into a polymer melt: role of diffusion and fragmentation. Crystal Growth & Design 2019, 19, (6), 3315-3328.

Purohit, H. S.; Trasi, N. S.; Osterling, D. J.; Stolarik, D. F.; Jenkins, G. J.; Gao, W.; Zhang, G. G. Z.; Taylor, L. S.  Assessing the impact of endogenously derived crystalline drug on the in vivo performance of amorphous formulations. Molecular Pharmaceutics 2019, 16, (8), 3617-3625.

Que, C.; Lou, X.; Zemlyanov, D. Y.; Mo, H.; Indulkar, A. S.; Gao, Y.; Zhang, G. G. Z.; Taylor, L. S.  Insights into the Dissolution Behavior of Ledipasvir–Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions. Molecular Pharmaceutics 2019, 16, (12), 5054-5067.

Saboo, S.; Mugheirbi, N. A.; Zemlyanov, D. Y.; Kestur, U. S.; Taylor, L. S.  Congruent release of drug and polymer: a “sweet spot” in the dissolution of amorphous solid dispersions. Journal of Controlled Release 2019, 298, 68-82.

Sherman, A. M.; Geiger, A. C.; Smith, C. J.; Taylor, L. S.; Hinds, J.; Stroud, P. A.; Simpson, G. J.  Stochastic Differential Scanning Calorimetry by Nonlinear Optical Microscopy. Analytical Chemistry 2019, 92, (1), 1171-1178.

Trasi, N. S.; Bhujbal, S.; Zhou, Q. T.; Taylor, L. S.  Amorphous solid dispersion formation via solvent granulation–A case study with ritonavir and lopinavir. International Journal of Pharmaceutics: X 2019, 1, 100035.

Tres, F.; Posada, M. M.; Hall, S. D.; Mohutsky, M. A.; Taylor, L. S.  The Effect of Promiscuous Aggregation on in Vitro Drug Metabolism Assays. Pharmaceutical Research. 2019, 36, (12), 170.

Voelker, A. L.; Verbeek, G.; Taylor, L. S.; Mauer, L. J.  Effects of emulsifiers on the moisture sorption and crystallization of amorphous sucrose lyophiles. Food Chemistry: X 2019, 3, 100050.

Thorat, A. A., Forny, L., Meunier, V., Taylor, L. S., and Mauer, L. J.  (2018). Effects of Mono-, Di-, and Tri-saccharides on the Stability and Crystallization of Amorphous Sucrose. Journal of Food Science. 83(11):2827-2839.

Indulkar, A. S., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2018). Crystallization from supersaturated solutions: Role of lecithin and composite simulated intestinal fluid. Pharmaceutical Research. 35(8):158.

Hsu, H., Taylor, L. S., and Harris, M. T. (2018) Impact of Additives on Heterogeneous Crystallization of Acetaminophen. International Journal of Chemical Engineering. 2018:1-7.

Wilson, V. Lou, X., Osterling, D. J., Stolarik, D. F., Jenkins, G., Gao, W., Zhang, G. G. Z., and Taylor, L. S. (2018).  Relationship between amorphous solid dispersion In Vivo absorption and In Vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport. Journal of Controlled Release. 292:172-182.

Mosquera-Giraldo, L. I., Borca, C. H., Parker, A. S., Dong, Y., Edgar, K. J., Beaudoin, S. P., Slipchenko, L.V, and Taylor, L. S. (2018). Crystallization Inhibition Properties of Cellulose Esters and Ethers for a Group of Chemically Diverse Drugs - Experimental and Computational Insight. Biomacromolecules. 19(12):4593-4606.

Moseson, D. E., Mugheirbi, N. A., Stewart, A. A., and Taylor, L. S. (2018). Nanometer-Scale Residual Crystals in a Hot Melt Extruded Amorphous Solid Dispersion: Characterization by Transmission Electron Microscopy. Crystal Growth and Design. 18(12):7633-7640.

Moseson, D. E. and Taylor, L. S. (2018). The application of temperature-composition phase diagrams for hot melt extrusion processing of amorphous solid dispersions to prevent residual crystallinity. International Journal of Pharmaceutics. 553(1-2):454-466.

Patel, M. A., Luthra, S., Shamblin, S. L., Arora, K., Krzyzaniak, J. F., and Taylor, L. S. (2018). Assessing the risk of salt disproportionation using crystal structure and surface topography analysis. Crystal Growth and Design. 18(11):7027-7040.

Mugheirbi, N. A., Mosquera-Giraldo, L. I., Borca, , Slipchenko, L.V, and Taylor, L. S. (2018). Phase Behavior of Drug-Hydroxypropyl Methylcellulose Amorphous Solid Dispersions Produced from Various Solvent Systems: Mechanistic Understanding of the Role of Polymer using Experimental and Theoretical Methods. Molecular Pharmaceutics. 15(8):3236-3251.

Arca, H., C., Bi, V., Mosquera-Giraldo, L. I.,  Xu, D., Taylor, L. S., and  Edgar, K. J. (2018). Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters. Biomacromolecules. 19(7):2351-2376.

Dening, T. J., and Taylor, L. S. (2018) Supersaturation Potential of Ordered Mesoporous Silica Delivery Systems. Part 1: Dissolution Performance and Drug Membrane Transport Rates. Molecular Pharmaceutics. 15(8):3489-3501.

Voelker, A.,  Miller, J., Running, C.A., Taylor, L. S. and Mauer, L. J. (2018). Chemical stability and reaction kinetics of two thiamine salts (thiamine mononitrate and thiamine chloride hydrochloride) in solution. Food Research International. 112:443-456.

Bhujbal, S.V., Zemlyanov, D.Y., Cavallaro, A., Mangal, S., Taylor, L. S. and Zhou, Q. T. (2018). Qualitative and Quantitative Characterization of Composition Heterogeneity on the Surface of Spray Dried Amorphous Solid Dispersion Particles by an Advanced Surface Analysis Platform with High Surface Sensitivity and Superior Spatial Resolution. Molecular Pharmaceutics. 15(5):2045-2053.

Mosquera-Giraldo, L. I., Li, N., Wilson, V. R., Nichols, B. L. B., Edgar, K. J., and Taylor, L. S. (2018). Influence of Polymer and Drug Loading on the Release Profile and Membrane Transport of Telaprevir. Molecular Pharmaceutics. 15(4):1700-1713.

Sugihara, H. and Taylor, L. S.  (2018) Evaluation of Pazopanib Phase Behavior Following pH-Induced Supersaturation. Molecular Pharmaceutics. 15(4):1690-1699.

Patel, M. A., Luthra, S., Shamblin, S. L.,  Arora, K.,  Krzyzaniak, J. F., and Taylor, L. S. (2018).Effect of excipient properties, water activity, and water content on the disproportionation of a pharmaceutical salt. International Journal of Pharmaceutics. 546 (1-2): 226-234.

Tres, F., Posada, M. M., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2018). Mechanistic Understanding of the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs. International Journal of Pharmaceutics. 543 (1-2):29-37.

Liu, S., Gao, C., Mosquera-Giraldo, L. I., Taylor, L. S., and Edgar, K. J. (2018) Selective Synthesis of Curdlan w-Carboxyamides by Staudinger Ylide Nucleophilic Ring-opening. Carbohydrate Polymers. 190:222-231.

Que, C., Gao, Y., Raina, S. A., Zhang, G. Z. Z., and Taylor, L. S. (2018) Paclitaxel Crystal Seeds with Different Intrinsic Properties and Their Impact on Dissolution of Paclitaxel-HPMCAS Amorphous Solid Dispersions. Crystal Growth and Design. 18(3):1548-1559.

Bhardwaj, V., Trasi, N. S., Zemlyanov, D. Y., and Taylor, L. S. (2018) Surface area normalized dissolution to study differences in itraconazole-copovidone solid dispersions prepared by spray-drying and hot melt extrusion. International Journal of Pharmaceutics. 540(1-2):106-119.

Purohit, H. S., Trasi, N. S., Sun, D. D., Chow, E. C. Y., Wen, H.,  Zhang, X., Gao, Y., and Taylor, L. S. (2018). Investigating the impact of drug crystallinity in amorphous tacrolimus capsules on pharmacokinetics and bioequivalence using discriminatory in vitro dissolution testing and PBPK modeling and simulation. Journal of Pharmaceutical Sciences.107(5):1330-1341.

Li, N., and Taylor, L.S. Tailoring supersaturation from amorphous solid dispersions. (2018) Journal of Controlled Release. 279:114-125.

Alin, J., Setiawan, N., Defrese, M., DiNunzio, J., Lau, H., Lupton, L., Xi, H., Su, Y., Nie, H., Hesse, N., Taylor, L. S., and Marsac, P. J. (2018). A novel approach for measuring room temperature enthalpy of mixing and associated solubility estimation of a drug in a polymer matrix. Polymer. 135(17):50-60.

Elkhabaz, A., Sarkar, S., Dinh, J. K., Simpson, G. J., and Taylor, L.S. (2018). Variation in the Supersaturation and Phase Behavior of Ezetimibe Amorphous Solid Dispersions Upon Dissolution in Different Biorelevant Media. Molecular Pharmaceutics. 15(1):193-206.

Tres, F., Hall, S. D., Mohutsky, M. A., and Taylor, L. S. (2018). Monitoring the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs Using Fluorescence Techniques. Journal of Pharmaceutical Sciences. 107(1):94-102.

Kalra, A., Luner, P.,  Taylor, L. S.,  Byrn, S. R., and Li, T. (2018). Gaining Thermodynamic Insight from Distinct Glass Formation Kinetics of Structurally Similar Organic Compounds. Journal of Pharmaceutical Sciences. 107(1):192-202.

Arca, H., C., Mosquera-Giraldo, L. I.,  Pereira, J. M. Sriranganathan, N., Taylor, L. S., Edgar, K. J. Rifampin Stability and Solution Concentration Enhancement through Amorphous Solid Dispersion in Cellulose ω-Carboxyalkanoate Matrices (2018). Journal of Pharmaceutical Sciences. 107(1):127-138.

Patel, M. A., Luthra, S., Shamblin, S. L.,  Arora, K.,  Krzyzaniak, J. F., and Taylor, L. S. (2018). Impact of solid-state form on the disproportionation of miconazole mesylate. Molecular Pharmaceutics. 15(1):40-52.

Winslow, C. J., Nichols, B. L. B, Novo, D. C. , Mosquera-Giraldo, L. I. , Taylor, L. S., Edgar, K. J., and Neilson, A. P. (2018). Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro. Carbohydrate Polymers. 182(15):149-158.

Arca, H., C., Mosquera-Giraldo, L. I., Pereira, J. M. Sriranganathan, N., Taylor, L. S., Edgar, K. J. (2017). Rifampin Stability and Solution Concentration Enhancement through Amorphous Solid Dispersion in Cellulose ω-Carboxyalkanoate Matrices. Journal of Pharmaceutical Sciences. 107(1):127-138. https://dx.doi.org/10.1016/j.xphs.2017.05.036

Thorat, A. A., Forny, L., Meunier, V., Taylor, L. S., and Mauer, L. J. (2017) Effects of chloride and sulfate salts on the inhibition or promotion of sucrose crystallization in initially amorphous sucrose-salt blends. Journal of Agricultural and Food Chemistry. 65(51):11259-11272. https://dx.doi.org/10.1021/acs.jafc.7b04746

Tian, B., Gao, W., Tao, X., Tang, X., and Taylor, L. S. (2017) Impact of Polymers on the Melt Crystal Growth Rate of Indomethacin Polymorphs. Crystal Growth and Design. 17(12):6467-6476. https://dx.doi.org/10.1021/acs.cgd.7b01145

Mugheirbi, N. A., Marsac, P. J. and Taylor, L. S. (2017) Insights into Water-Induced Phase Separation in Itraconazole-hydroxypropylmethyl cellulose Spin Coated and Spray Dried Dispersions. Molecular Pharmaceutics. 14(12):4387-4402. https://dx.doi.org/10.1021/acs.molpharmaceut.7b00499

Hate, S. S., Reutzel-Edens, S. M., and Taylor, L. S. (2017) Absorptive Dissolution Testing of Supersaturating Systems: Impact of Absorptive Sink Conditions on Solution Phase Behavior and Mass Transport. Molecular Pharmaceutics. 14(11):4052-4063. https://dx.doi.org/10.1021/acs.molpharmaceut.7b00740

Purohit, H. S., and Taylor, L. S. (2017). Phase Behavior of Ritonavir Amorphous Solid Dispersions During Hydration and Dissolution. Pharmaceutical Research. 34(12):2842-2861. https://dx.doi.org/10.1007/s11095-017-2265-5

Arca, H., C., Mosquera-Giraldo, L. I., Dahal, D., Taylor, L. S., and Edgar, K. J. (2017). Multidrug, Anti-HIV Amorphous Solid Dispersions: Nature and Mechanisms of Impacts of Drugs on Each Other’s Solution Concentrations. Molecular Pharmaceutics. 14(11):3617-3627. https://dx.doi.org/10.1021/acs.molpharmaceut.7b00203

Mugheirbi, N. A., O’Connel, P., Taylor, L. S., and Tajber, L. (2017) A comparative study on the performance of inert and functionalized spheres coated with solid dispersions made of two structurally related antifungal drugs. Molecular Pharmaceutics. 14(11):3718-3728. https://dx.doi.org/10.1021/acs.molpharmaceut.7b00482

Correa-Soto, C., Trasi, N. S., Schmitt, P. D. Su, Y., Liu, Z., Variankaval, N., Marsac, P. J., Simpson, G. J., and Taylor, L. S. (2017). Second Harmonic Generation Microscopy as a Tool for the Early Detection of Crystallization in Spray Dried Dispersions. Journal of Pharmaceutical and Biomedical Analysis. 146:86-95. https://dx.doi.org/10.1016/j.jpba.2017.07.066

Xie, T., Gao, W., and Taylor, L. S. (2017). Impact of Eudragit EPO and Hydroxypropyl Methylcellulose on Drug Release Rate, Supersaturation, Precipitation Outcome and Redissolution Rate of Indomethacin Amorphous Solid Dispersions. International Journal of Pharmaceutics. 531(1):313-323. https://dx.doi.org/10.1016/j.ijpharm.2017.08.099

Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Patel, S., Litster, J. D., and Taylor, L. S. (2017). Compositional Effect of Complex Biorelevant Media on the Crystallization Kinetics of an Active Pharmaceutical Ingredient. CrystEngComm. 19:4797-4806. https://dx.doi.org/10.1039/C7CE01128H

Saboo, S., and Taylor, L. S. (2017). Water-induced Phase Separation of Miconazole-Poly (Vinylpyrrolidone-Co-Vinyl Acetate) Amorphous Solid Dispersions: Insights with Confocal Fluorescence Microscopy. International Journal of Pharmaceutics. 529(1-2):654-666. https://dx.doi.org/10.1016/j.ijpharm.2017.07.034

Trasi, N. S., Purohit, H., and Taylor, L. S. (2017). Evaluation of the Crystallization Tendency of Commercially Available Amorphous Tacrolimus Formulations Exposed to Different Stress Conditions. Pharmaceutical Research. 34(10):2142-2155. https://dx.doi.org/10.1007/s11095-017-2221-4

Arioglu-Tuncil, S., Bhardwaj, V., Taylor, L. S. and Mauer, L. J. (2017). The Crystallization Inhibitor Properties of Different Polymers in Thiamine Chloride Hydrochloride Amorphous Solid Dispersions. Food Research International. 99(1):263-374. https://dx.doi.org/10.1016/j.foodres.2017.05.021

Indulkar, A. S., Waters, J. E., Mo, H., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2017). Origin of Nanodroplet Formation upon Dissolution of an Amorphous Solid Dispersion: A Mechanistic Isotope Scrambling Study. Journal of Pharmaceutical Sciences. 106(8):1998-2008. https://dx.doi.org/10.1016/j.xphs.2017.04.015

Kalra, A., Tishmack, P., Lubach, J. W., Munson, E., Taylor, L. S., Byrn, S. R., and Li, T. (2017). Impact of Supramolecular Aggregation on the Crystallization Kinetics of Organic Compounds from the Supercooled Liquid State. Molecular Pharmaceutics. 14(6):2126–2137. https://dx.doi.org/10.1021/acs.molpharmaceut.7b00245

Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Patel, S., Litster, J. D., and Taylor, L. S. (2017). Impact of Bile Salts on Solution Crystal Growth Rate and Residual Supersaturation of an Active Pharmaceutical Ingredient. Crystal Growth and Design. 17(6):3528–3537. https://dx.doi.org/10.1021/acs.cgd.7b00464

Purohit, H.S., Ormes, J. D., Saboo, S., Su, Y., Lamm, M. S., Mann, A. K. P., and Taylor, L. S. (2017). Insights into Nano- and Micron-scale Phase Separation in Amorphous Solid Dispersions using Fluorescence-based Techniques in Combination with Solid State Nuclear Magnetic Resonance Spectroscopy. Pharmaceutical Research. 34(7):1364-1377. https://dx.doi.org/10.1007/s11095-017-2145-z

Li, N., Gilpin, C. J. and Taylor, L. S. (2017) Understanding the impact of water on the miscibility and microstructure of amorphous solid dispersions – An AFM/LCR and TEM/EDX study. Molecular Pharmaceutics. 14(5):1691–1705. https://dx.doi.org/10.1021/acs.molpharmaceut.6b01151

Dong, Y., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2017). Tandem Modification of Amphiphilic Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-metathesis and Thiol-Michael Addition. Polymer Chemistry. 8:3129-3139. https://dx.doi.org/10.1039/C7PY00228A

 

Icten, E., Purohit, H. S., Wallace, C., Giridhar, A., Taylor, L. S., Nagy, Z. K., Reklaitis, G. V. (2017). Dropwise Additive Manufacturing of Pharmaceutical Products for Amorphous and Self Emulsifying Drug Delivery Systems. International Journal of Pharmaceutics. 524(1-2):424-432. https://dx.doi.org/10.1016/j.ijpharm.2017.04.003.

Indulkar, A. S., Mo, H., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2017). Impact of micellar surfactant on supersaturation and insight into solubilization mechanisms in supersaturated solutions. Pharmaceutical Research. 34(6):1276-1296. https://dx.doi.org/10.1007/s11095-017-2144-0

Lu, J., Ormes, J. D., Lowinger, M., Mann, A. K. P., Xu, W., Litster, J. D., and Taylor, L. S. (2017). Maintaining Supersaturation of Active Pharmaceutical Ingredient Solutions with Biologically Relevant Bile Salts. Crystal Growth and Design. 17(5):2782–2791. https://dx.doi.org/10.1021/acs.cgd.7b00237

Thorat, A., Marrs, K. N., Ghorab, M. K., Meunier, V., Forny, L., Taylor, L. S, and Mauer, L. J. (2017). Moisture-Mediated Interactions between Amorphous Maltodextrins and Crystalline Fructose. Journal of Food Science. 82(5):1142–1156. https://dx.doi.org/10.1111/1750-3841.13676

Lu, J., Ormes, J. D., Lowinger, M., Xu, W., Mitra, A., Mann, A. K. P., Litster, J. D., and Taylor, L. S. (2017). Impact of Endogenous Bile Salts on the Thermodynamics of Supersaturated Active Pharmaceutical Ingredient Solutions. Crystal Growth and Design. 17(3):1264-1275. https://dx.doi.org/10.1021/acs.cgd.6b01664

Arca, H.C., Mosquera-Giraldo, L.I., Taylor, L.S., and Edgar, K. J. (2017). Synthesis and characterization of alkyl cellulose ω-carboxyesters for amorphous solid dispersion. Cellulose. 24:609-625. https://dx.doi.org/10.1007/s10570-016-1156-y

Nie, H., Xu, W., Taylor, L. S., Marsac, P. J., and Byrn, S. R. (2017). Crystalline solid dispersion-a strategy to slowdown salt disproportionation in solid state formulations during storage and wet granulation. International Journal of Pharmaceutics. 517(1-2):203-215. https://dx.doi.org/10.1016/j.ijpharm.2016.12.014

Sato, T. and Taylor, L. S. (2017). Acceleration of the crystal growth rate of low molecular weight organic compounds in supercooled liquids in the presence of polyhydroxybutylate. CrystEngComm. 19:80-87. https://dx.doi.org/10.1039/C6CE02177H

Gilley, A. D., Arca, H. C., Nichols, B. L. B., Mosquera-Giraldo, L. I., Taylor, L. S., Edgar, K. J., Neilson, A. P. (2107). Novel Cellulose-Based Amorphous Solid Dispersions Enhance Quercetin Solution Concentrations In Vitro. Carbohydrate Polymers. 157:86-93. https://dx.doi.org/10.1016/j.carbpol.2016.09.067

Xie, T., and Taylor, L. S. (2017). Effect of Temperature and Moisture on the Physical Stability of Binary and Ternary Amorphous Solid Dispersions of Celecoxib. Journal of Pharmaceutical Sciences. 106(1):100-110. https://dx.doi.org/10.1016/j.xphs.2016.06.017

Trasi, N. S., Purohit, H. S., Wen, H., Sun, D. D., and Lynne S. Taylor (2017). Non-sink dissolution behavior and solubility limit of commercial tacrolimus amorphous formulations. Journal of Pharmaceutical Sciences. 106(1):264-272. https://dx.doi.org/10.1016/j.xphs.2016.09.016

Taylor, L. S., Rantanen, J., Paradkar, A., Kawashima, Y., and Zhang, J. (2017). Professor Peter York- A distinguished career in powders, processing and particle design. Journal of Pharmaceutical Sciences. 106(1):2-4. https://dx.doi.org/10.1016/j.xphs.2016.09.006

 

Li, N., Mosquera-Giraldo, L. I., Borca, C. H., Ormes, J. D., Lowinger, M. Higgins, J. D., Slipchenko, L.V., and Taylor, L. S. (2016)A Comparison of the Crystallization Inhibition Properties of Bile SaltsCrystal Growth and Design. 16(12):7286-7300. 

Tian, B., Tang, X., and Taylor, L. S. (2016). Investigating the Correlation between Miscibility and Physical Stability of Amorphous Solid Dispersions Using Fluorescence-based Techniques. Molecular Pharmaceutics. 13(11):3988-4000. 

Mosquera-Giraldo, L. I., Borca, C. H., Meng, X., Edgar, K. J., Slipchenko, L.V, and Taylor, L. S. (2016). Mechanistic Design of Chemically Diverse Polymers with Applications in Oral Drug DeliveryBiomacromolecules. 17(11):3659-3671. 

Nie, H., Su, Y., Zhang, M., Song, Y., Leone, A., Taylor, L.S., Marsac, P. J., Li, T., and Byrn, S. R. (2016). Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions. Molecular Pharmaceutics. 13(11):3964-3975. 

Lu, M. and Taylor, L. S. (2016). Vemurafenib: A Tetramorphic System Displaying Concomitant Crystallization from the Supercooled Liquid. Crystal Growth and Design. 16(10):6033-6042. 

Nie, H., Xu, W., Ren, J., Taylor, L. S., Marsac, P. J., John, C. T., and Byrn, S. R. (2016). Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State FormulationsMolecular Pharmaceutics. 13(10):3541-3552. 

Dong, Y., Mosquera-Giraldo, L. I, Troutman, J., Skogstad, B., Taylor, L. S. and Edgar, K. J. (2016). Amphiphilic Hydroxyalkyl Cellulose Derivatives for Amorphous Solid Dispersion Prepared by Olefin Cross-Metathesis. Polymer Chemistry. 7:4953-4963.

Sun, D. D., Wen, H. and Taylor, L. S. (2016). Non-sink dissolution conditions for predicting product quality and in vivo performance of supersaturating drug delivery systemsJournal of Pharmaceutical Sciences. 105(9):2477-2488. 

Sato, T. and Taylor, L. S. (2015). Chiral Discrimination by a Cellulose Polymer: Differential Crystallization Inhibition of Enantiomers in Amorphous Dispersions. CrystEngComm. 17:5046-5053.

Schmitt, P. D., Trasi, N. S., Taylor, L. S. and Simpson, G. S. Finding the Needle in the Haystack – Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy. (2015) Molecular Pharmaceutics. 12(7):2378-2383. 

Indulkar, A. S., Gao, Y., Raina, S. A., Zhang, G. G. Z., and Taylor, L. S. (2016). Exploiting the phenomenon of liquid-liquid phase separation for enhanced and sustained membrane transport of a poorly water soluble drug. Molecular Pharmaceutics. 13(6):2059-2069. 

Schram, C. J., Smyth, R. J., Taylor, L. S. and Beaudoin, S. P. (2016). Understanding Crystal Growth Kinetics in the Absence and Presence of a Polymer Using a Rotating Disk Apparatus. Crystal Growth and Design. 16(5):2640-2645. 

Li, N., Ormes, J. D. and Taylor, L. S. (2016). Leaching of Lopinavir Amorphous Solid Dispersions in Acidic MediaPharmaceutical Research. 33(7):1723-1735. 

Taylor, L. S. and Zhang, G. G. Z. (2016) Physical Chemistry of Supersaturated Solutions and Implications for Oral AbsorptionAdvanced Drug Delivery Reviews. 101:122-142. 

Alhalaweh, A., Bergström, C. A. S. and Taylor, L. S. (2016). Compromised in vitro dissolution and membrane transport of multidrug amorphous formulationsJournal of Controlled Release.229:172-182

Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Characterization of Highly Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and Phase Transitions. Pharmaceutical Research. 33(5):1276-1288. 

Li., N. and Taylor, L. S. (2016). Nanoscale Infrared, Thermal, and Mechanical Characterization of Telaprevir-Polymer Miscibility in Amorphous Solid Dispersions Prepared by Solvent Evaporation. Molecular Pharmaceutics. 13(3):1123-1136. 

Schram, C. J., Beaudoin, S. P. and Taylor, L. S. (2016). Polymer Inhibition of Crystal Growth by Surface Poisoning. Crystal Growth and Design. 16(4):2094-2103. 

Xie, T., and Taylor, L. S. (2016). Improved Release of Celexocib from High Drug Loading Amorphous Solid Dispersions Formulated with Polyacrylic Acid and Cellulose Derivatives. Molecular Pharmaceutics.13(3):873-884. 

Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A. and Taylor, L. S. (2016). Supersaturation Potential of Salt, Co-Crystal and Amorphous Forms of a Model Weak BaseCrystal Growth and Design. 16(2):737-748.

Dong, Y., Mosquera-Giraldo, L. I., Taylor, L. S. and Edgar, K. J. (2016). Design of Functionalized Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-MetathesisBiomacromolecules. 17(2):454-465.

Jackson, M. J., Kestur, U. S., Hussain, M. A., and Taylor, L. S. (2016). Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type. Molecular Pharmaceutics. 13(1):223-231. 

Xie, T., and Taylor, L. S. (2016). Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations. Pharmaceutical Research. 33(3):739-750.

Nie, H., Liu, Z., Marks, B. C., Taylor, L. S., Byrn, S. R. and Marsac, P. J. (2016). Analytical Approaches to Investigate Salt Disproportionation in Tablet Matrices by Raman Spectroscopy and Raman MappingJournal of Pharmaceutical and Biomedical Analysis. 118:328-337

Allan, M., Taylor, L. S. and Mauer, L. J. (2016). Common-Ion Effects on the Deliquescence Lowering of Crystalline Ingredient Blends. Food Chemistry. 195:2-10.

Li, N., Taylor, L. S. and Mauer, L. J. (2016). Heat Transport Model for the Deliquescence Kinetics of Crystalline Ingredients and Mixtures. Journal of Food Engineering. 169:298-308. 

Nie, H., Mo, H., Zhang, M., Song, Y., Fang, K., Taylor, L. S., Li, T. and. Byrn, S. R. (2015). Investigating the interaction pattern and structural elements of a drug-polymer complex at the molecular level. Molecular Pharmaceutics. 12(7)2459-2468. 

Trasi, N. S. and Taylor, L. S. (2015). Thermodynamics of Highly Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs – Impact of a Second Drug on the Solution Phase Behavior and Implications for Combination Products. Journal of Pharmaceutical Sciences. 104(8):2583-2593.

Indulkar, A., Box, K. J., Taylor, R., Ruiz, R., and Taylor, L. S. (2015). pH-Dependent Liquid-Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs. Molecular Pharmaceutics. 12(7):2365-2377. 

Purohit, H. S. and Taylor, L. S. Phase Separation Kinetics in Amorphous Solid Dispersions Upon Exposure to Water. (2015) Molecular Pharmaceutics. 12(5):1623-1635. 

Chen, J., Mosquera-Giraldo L., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015). Bile Salts as Crystallization Inhibitors of Supersaturated Solutions of Poorly Water-Soluble Compounds. Crystal Growth and Design. 15(6):2593-2597.

Raina, S. A., Van Eerdenbrug, B., Alonzo, D. E., Mo, H., Zhang, G. G. Z., Gao, Y. and Taylor, L. S. (2015). Trends in the Precipitation and Crystallization Behavior of Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs Assessed using Synchrotron Radiation. Journal of Pharmaceutical Sciences. 104(6):1981-1992.

Içten, E., Giridhar, A., Taylor, L. S., Nagy, Z. K., Reklaitis, G. V. (2015). Dropwise Additive Manufacturing of Pharmaceutical Products for Melt-Based Dosage Forms. Journal of Pharmaceutical Sciences. 104(5):1641-1649.

Toth, S., Schmitt, P. D., Snyder, G. R., Trasi, N. S., George, I. A.,  Taylor, L. S. and Simpson, G. J. (2015) Ab Initio Prediction of the Diversity of Second Harmonic Generation from Pharmaceutically Relevant Materials. Crystal Growth Design. 15(2):581-586. 

Chen, J., Ormes, J. D., Higgins, J. D. and Taylor, L. S. (2015) Impact of Surfactants on the Crystallization of Aqueous Suspensions of Celecoxib Amorphous Solid Dispersion Spray Dried Particles. Molecular Pharmaceutics. 12(2):533-541.

Trasi, N. S., Abbou-Oucherif, K., Litster, J. D. and Taylor, L. S. (2015)  Evaluating the Influence of Polymers on Nucleation and Growth in Supersaturated Solutions of Acetaminophen. CrystEngComm. 17:1242-1248.

Mosquera-Giraldo L., and Taylor, L. S. (2015) Glass-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Telaprevir. (2015) Molecular Pharmaceutics. 12(2):496-501.

Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A. and Taylor, L. S. (2015). Assessment of the Amorphous “Solubility” of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches. Molecular Pharmaceutics. 12(2):484-495. 

Hsieh, Y-L., and Taylor, L. S. (2015). Salt Stability - Effect of Particle Size, Relative Humidity, Temperature and Composition on Salt to Free Base Conversion. Pharmaceutical. Research. 32(2):549-561.

Schram, C. J., Beaudoin, S. P. and Taylor, L. S. (2015). Impact of Polymer Conformation on the Crystal Growth Inhibition of a Poorly Water Soluble Drug in Aqueous Solution. Langmuir. 31(1):171-179.

 Hsu, H-Y, Adigun, O. O., Taylor, L. S., Murad, S. and Harris, M. T. (2015). Impact of Surface Chemistry on Crystallization of Acetaminophen.  Chemical Engineering Science. 126:1-9.

Lipasek, R.A., Li, N., Taylor, L. S. and Mauer, L. J. (2015) Effect of temperature and initial moisture content on the chemical stability and color change of various forms of vitamin C. International Journal of Food Properties. 18(4):862-879.